{"id":"W2606931784","doi":"10.1128/msphere.00120-17","title":"Discovery of a Novel Antifungal Agent in the Pathogen Box","year":2017,"lang":"en","type":"article","venue":"mSphere","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Deutsche Forschungsgemeinschaft; University of British Columbia; Medicines for Malaria Venture; Government of Canada","keywords":"Cryptococcus neoformans; Candida albicans; Antifungal; Human pathogen; Pathogen; Fungal pathogen; Potency; Microbiology; Biology; Cryptococcus; Human immunodeficiency virus (HIV); Antifungal drugs; Virology; Bacteria; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003388291,0.00008370467,0.0002079117,0.00001015333,0.00009514608,0.00003862249,0.0002323596,0.00005483131,0.0000611942],"category_scores_gemma":[0.0002375916,0.00005052771,0.0001037575,0.00004144834,0.0001390575,0.0001256133,0.00004973671,0.0001387499,0.00001178698],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002163353,"about_ca_system_score_gemma":0.0000734499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001769669,"about_ca_topic_score_gemma":0.0008354976,"domain_scores_codex":[0.9992289,0.00002387565,0.000186683,0.0001693701,0.000234369,0.0001568252],"domain_scores_gemma":[0.998997,0.00004001389,0.00009611075,0.0008066492,0.0000347735,0.00002540143],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002190221,0.0004557692,0.9016103,0.0001313204,0.00001904815,0.00007895278,0.0004574279,9.339523e-7,0.09237371,0.0006511941,0.001097005,0.002905346],"study_design_scores_gemma":[0.0008539379,0.00008539798,0.9947391,0.000161646,0.00002573725,0.00000658021,0.0007984039,0.00003046925,0.00205188,0.00007138835,0.001116447,0.00005903559],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9765654,0.0003541208,0.0002620096,0.0005614134,0.00007676932,0.0002254214,0.00002659884,0.000005915332,0.02192231],"genre_scores_gemma":[0.9970413,0.00004988233,0.0002521434,0.000188746,0.00007006854,0.000006090429,0.000005076676,0.000007402549,0.002379299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09312882,"threshold_uncertainty_score":0.206046,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04377501810748016,"score_gpt":0.3190852887898737,"score_spread":0.2753102706823936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}