{"id":"W2606957323","doi":"10.2147/dddt.s131213","title":"Justification of disintegration testing beyond current FDA criteria using in vitro and in silico models","year":2017,"lang":"en","type":"article","venue":"Drug Design Development and Therapy","topic":"Drug Solubulity and Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"University of Alberta","keywords":"Dissolution; Dissolution testing; Materials science; Diffusion; Chemistry; Biochemical engineering; Computer science; Thermodynamics; Physics; Engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01856071,0.001350656,0.001435268,0.001350626,0.0007481202,0.002804516,0.003093662,0.002328173,0.002294515],"category_scores_gemma":[0.02950296,0.0007551986,0.001632063,0.0006640485,0.001935196,0.001781412,0.001636482,0.002682336,0.001300146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001432938,"about_ca_system_score_gemma":0.002443349,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002311536,"about_ca_topic_score_gemma":0.002459412,"domain_scores_codex":[0.9801384,0.006796137,0.00171887,0.001590588,0.009315977,0.0004399256],"domain_scores_gemma":[0.9668706,0.01773711,0.00351924,0.004896077,0.006626837,0.0003501411],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.002246993,0.001521482,0.01173081,0.00598595,0.0004031215,0.001542653,0.0008837506,0.06029695,0.6302028,0.07567411,0.01230064,0.1972107],"study_design_scores_gemma":[0.0003261236,0.005485251,0.006618979,0.001795285,0.0004759315,0.001789752,0.0003846661,0.2357963,0.5731769,0.02281304,0.1510256,0.0003123132],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.1425218,0.0173331,0.7887509,0.009559243,0.001549439,0.001879578,0.002363992,0.001770808,0.03427112],"genre_scores_gemma":[0.626534,0.01056599,0.34866,0.003152129,0.0002864915,0.001165287,0.002097953,0.0004938943,0.007044229],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01856071,"threshold_uncertainty_score":0.09815955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3897675016050524,"score_gpt":0.4523156752787801,"score_spread":0.06254817367372767,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}