{"id":"W2607023270","doi":"10.1021/acsomega.6b00481","title":"Hydroxyl Ketone-Based Histone Deacetylase Inhibitors To Gain Insight into Class I HDAC Selectivity versus That of HDAC6","year":2017,"lang":"en","type":"article","venue":"ACS Omega","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Fondation Pierre Mercier; Académie des Sciences, Institut de France; Centre National de la Recherche Scientifique; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Agence Nationale de la Recherche","keywords":"Selectivity; Linker; Chemistry; HDAC6; HDAC1; Gene isoform; Histone deacetylase; Ketone; Biochemistry; Combinatorial chemistry; Histone; Stereochemistry; Gene; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006377562,0.0003831779,0.0004455944,0.0002515612,0.0005296959,0.00008662425,0.0009306413,0.0003994495,0.00001186233],"category_scores_gemma":[0.001336101,0.000402656,0.0002203144,0.0002238045,0.000507632,0.00002925081,0.0005662945,0.0003528146,0.00008634207],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003009314,"about_ca_system_score_gemma":0.0005085355,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000751203,"about_ca_topic_score_gemma":0.001384457,"domain_scores_codex":[0.9972932,0.000198114,0.0003878203,0.0008366762,0.0006410652,0.0006430688],"domain_scores_gemma":[0.9970222,0.00008869521,0.0003005525,0.001893662,0.0002943352,0.0004005596],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001214812,0.0002680688,0.0009412912,0.00006506747,0.00008275585,0.00002726666,0.0002369341,0.0001236839,0.9788772,0.00003533298,0.01476014,0.003367382],"study_design_scores_gemma":[0.002274305,0.0008461816,0.0007384297,0.00004676793,0.00002462668,0.000004015889,0.0000306785,0.00008232069,0.9283022,0.00001428324,0.06722197,0.0004141692],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921967,0.0004801337,0.0002663437,0.001006623,0.0006522202,0.0005057239,0.00003921097,0.00003558786,0.00481741],"genre_scores_gemma":[0.9971257,0.00003725043,0.0005411971,0.0001800451,0.0003826016,0.00008959893,0.00009359316,0.0000801757,0.001469779],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05246183,"threshold_uncertainty_score":0.9998425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02506079298136625,"score_gpt":0.3250688221078979,"score_spread":0.3000080291265317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}