{"id":"W2607023270","doi":"10.1021/acsomega.6b00481","title":"Hydroxyl Ketone-Based Histone Deacetylase Inhibitors To Gain Insight into Class I HDAC Selectivity versus That of HDAC6","year":2017,"lang":"en","type":"article","venue":"ACS Omega","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Fondation Pierre Mercier; Académie des Sciences, Institut de France; Centre National de la Recherche Scientifique; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Agence Nationale de la Recherche","keywords":"Selectivity; Linker; Chemistry; HDAC6; HDAC1; Gene isoform; Histone deacetylase; Ketone; Biochemistry; Combinatorial chemistry; Histone; Stereochemistry; Gene; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001267691,0.000264258,0.0002026246,0.0001169402,0.00007784586,0.0001898412,0.000206688,0.0001554104,0.003874329],"category_scores_gemma":[0.00005733005,0.0001103071,0.0001609568,0.0001297937,0.0001103751,0.000252351,0.00009121001,0.0004347865,0.0005852464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002521774,"about_ca_system_score_gemma":0.000145848,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007531045,"about_ca_topic_score_gemma":0.001372816,"domain_scores_codex":[0.9999503,0.000006208443,0.000003885104,0.00001180194,0.00001458221,0.00001321757],"domain_scores_gemma":[0.9999685,0.000008511419,0.000006957505,0.000004267563,0.000005812897,0.00000593443],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009339888,0.0000143512,0.00007858968,0.00004158966,0.000005065339,0.00002469444,0.000005449646,0.0001177304,0.997319,0.0001131992,0.00007511777,0.002111644],"study_design_scores_gemma":[0.00001680128,0.000147571,0.0009777676,0.000002427035,0.000008542047,0.00008163095,0.000007351116,0.001061236,0.9951077,0.00003312733,0.002552608,0.000003172924],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9633827,0.008025846,0.01580699,0.0003416777,0.00008257711,0.00008418621,0.0009857583,0.0003651171,0.01092518],"genre_scores_gemma":[0.9718684,0.005257439,0.01416683,0.0001626237,0.00002386667,0.00004188261,0.0009024282,0.0000550787,0.00752147],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003874329,"threshold_uncertainty_score":0.01296091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02506079298136625,"score_gpt":0.3250688221078979,"score_spread":0.3000080291265317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}