{"id":"W2607038075","doi":"10.1038/srep46525","title":"G protein-coupled KISS1 receptor is overexpressed in triple negative breast cancer and promotes drug resistance","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Hypothalamic control of reproductive hormones","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Lawson Health Research Institute; Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Triple-negative breast cancer; Cancer research; Breast cancer; Abcg2; Receptor tyrosine kinase; Estrogen receptor; Kisspeptin; Drug resistance; Biology; Cancer; Progesterone receptor; Medicine; Receptor; Internal medicine; ATP-binding cassette transporter; Transporter; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007343424,0.0001354014,0.0002001814,0.0002905448,0.0001206539,0.0002483664,0.00006227867,0.0001568308,0.001236972],"category_scores_gemma":[0.000126638,0.00008864926,0.0001026759,0.0001557567,0.0001949603,0.00009751685,0.000159308,0.000235652,0.0002369988],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002263765,"about_ca_system_score_gemma":0.0001407695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004114014,"about_ca_topic_score_gemma":0.000490605,"domain_scores_codex":[0.9999537,0.000007911977,0.000002599053,0.000008788457,0.00001354735,0.00001333283],"domain_scores_gemma":[0.9999409,0.000008123054,0.00002739163,0.00000307013,0.000004267733,0.00001616643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007250166,0.00003942345,0.0141928,0.0001408202,0.00002962778,0.002539669,0.0001367372,0.0001169574,0.9682612,0.0004262765,0.0006507814,0.01274068],"study_design_scores_gemma":[0.0001469319,0.001553215,0.5493827,0.00008680372,0.000188949,0.03597594,0.0008931689,0.001963491,0.3810872,0.001425119,0.02725322,0.00004321911],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929079,0.004847877,0.000298692,0.0001918042,0.00002560339,0.000007692447,0.0001303153,0.00003966299,0.001550517],"genre_scores_gemma":[0.9962299,0.002314012,0.0002238148,0.00005763306,0.00001518325,0.000006211537,0.0001034221,0.000007169414,0.00104264],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001236972,"threshold_uncertainty_score":0.004138112,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0129144725590054,"score_gpt":0.2674883670887993,"score_spread":0.2545738945297938,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}