{"id":"W2607148153","doi":"10.1182/blood.v128.22.605.605","title":"Linking Subclonal Genetic Diversity with Functional Heterogeneity Identifies Diagnosis Subclones Destined to Relapse","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"","keywords":"Biology; clone (Java method); Somatic evolution in cancer; SNP array; Disease; Leukemia; Genetics; Genetic heterogeneity; Exome sequencing; Cancer research; Cancer; Immunology; Mutation; Oncology; Phenotype; Medicine; Internal medicine; Genotype; Gene; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001586081,0.0001311114,0.0002083963,0.000595774,0.0001475941,0.0004334895,0.0001450798,0.0002108417,0.001580557],"category_scores_gemma":[0.0003395354,0.00008768492,0.000140788,0.0002972287,0.0001800289,0.0001220526,0.0002939132,0.0002956334,0.0003269949],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001587555,"about_ca_system_score_gemma":0.00007140941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000410389,"about_ca_topic_score_gemma":0.000526775,"domain_scores_codex":[0.9998504,0.00002198349,0.00001234471,0.0000451121,0.00003849211,0.00003157587],"domain_scores_gemma":[0.9997678,0.00006476876,0.00007097268,0.00002837271,0.0000311473,0.00003684525],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006949566,0.00004728774,0.2967783,0.00004666137,0.00004708789,0.0003473078,0.0001964244,0.0002500012,0.6896093,0.0001561087,0.0001481977,0.01167833],"study_design_scores_gemma":[0.00001296511,0.0003428051,0.9149692,0.000008077212,0.00006072056,0.002837246,0.0002600565,0.001840784,0.07807443,0.0002475499,0.001337808,0.000008380888],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991472,0.0001358046,0.0003031431,0.00001451251,0.000001186327,0.000003706448,0.0001769956,0.00001113677,0.0002062927],"genre_scores_gemma":[0.9992355,0.00005450252,0.0002290743,0.00001653148,0.000002445568,0.000003591825,0.0003179048,0.000004907576,0.0001354814],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001580557,"threshold_uncertainty_score":0.005287528,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02585914565056471,"score_gpt":0.2512911073637927,"score_spread":0.225431961713228,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}