{"id":"W2607166912","doi":"10.1038/ng.3838","title":"Spatial heterogeneity in medulloblastoma","year":2017,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":143,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Ontario Institute for Cancer Research; Simon Fraser University; McGill University Health Centre; McGill University; University of Toronto; Montreal Children's Hospital; SickKids Foundation; BC Cancer Agency; Princess Margaret Cancer Centre; University Health Network; St. Michael's Hospital; Canada's Michael Smith Genome Sciences Centre; Hospital for Sick Children","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Cancer Institute; Francis Crick Institute","keywords":"Genetic heterogeneity; Transcriptome; Biology; Spatial heterogeneity; Tumour heterogeneity; Homogeneous; Somatic cell; Cancer research; Glioma; Somatic evolution in cancer; Targeted therapy; Medulloblastoma; Biopsy; Tumor heterogeneity; Computational biology; Gene; Genetics; Phenotype; Cancer; Pathology; Medicine; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009980702,0.0001411268,0.000122411,0.00003124396,0.0001278864,0.0000737745,0.0004598724,0.0004115116,0.000009632412],"category_scores_gemma":[0.0002138538,0.0001486457,0.00006820991,0.00002054141,0.0000820227,0.000001677806,0.0002844767,0.0002226468,0.00001011193],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002017431,"about_ca_system_score_gemma":0.00008682651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006576347,"about_ca_topic_score_gemma":0.004363505,"domain_scores_codex":[0.9991429,0.00001565966,0.0001490662,0.0003305273,0.0001189476,0.0002428374],"domain_scores_gemma":[0.9989234,0.000007427704,0.00009604565,0.000830239,0.00006009832,0.00008274664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002353786,0.000174079,0.7554854,0.00002798746,0.00006810961,0.00005009115,0.00004505602,0.0004396402,0.1883412,0.0001358835,0.006044677,0.04895257],"study_design_scores_gemma":[0.0009000925,0.000197341,0.5126786,0.00001134624,0.00001254429,0.00001257164,0.000006763796,0.0001954092,0.3670141,0.0002172462,0.1184734,0.0002806681],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941615,0.002657265,0.0002499805,0.0002199219,0.0007849414,0.0001295566,0.00004522767,0.000004900412,0.001746704],"genre_scores_gemma":[0.9968637,0.0008713315,0.0009071107,0.0004763849,0.0007136394,0.000009926463,0.00004153762,0.00002300527,0.00009339766],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2428068,"threshold_uncertainty_score":0.6061596,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00689660226055799,"score_gpt":0.2724231199390668,"score_spread":0.2655265176785088,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}