{"id":"W2607232993","doi":"10.1016/j.celrep.2017.03.049","title":"Cooperativity Enables Non-neutralizing Antibodies to Neutralize Ebolavirus","year":2017,"lang":"en","type":"article","venue":"Cell Reports","topic":"Viral Infections and Outbreaks Research","field":"Medicine","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Public Health Agency of Canada","funders":"National Institute of Allergy and Infectious Diseases; U.S. Army; Defense Threat Reduction Agency; National Institutes of Health; Public Health Agency of Canada","keywords":"Neutralization; Antibody; Ebolavirus; Ebola virus; Neutralizing antibody; Virology; Monoclonal antibody; Cooperativity; IC50; Glycan; Potency; Biology; Chemistry; Virus; Glycoprotein; Immunology; Molecular biology; Cell culture; In vitro; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000375234,0.0001651367,0.0003306856,0.0001109277,0.0007688133,0.0002582351,0.00009220299,0.00008890784,0.0001687214],"category_scores_gemma":[0.0001774957,0.0001332586,0.0001187268,0.00008266993,0.000113512,0.0002122579,0.000159105,0.0002244602,0.0001159969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004950624,"about_ca_system_score_gemma":0.0001371305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001591741,"about_ca_topic_score_gemma":0.0001659896,"domain_scores_codex":[0.9986483,0.00002272415,0.0002936446,0.0003855434,0.0002473148,0.0004024128],"domain_scores_gemma":[0.9984358,0.00002111646,0.0001312382,0.0009112715,0.0001962879,0.0003042944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006417074,0.0002736533,0.1728253,0.0001799118,0.00004375434,0.004812259,0.0002765117,0.00004207392,0.8008195,0.00004812813,0.01561991,0.004994777],"study_design_scores_gemma":[0.0003584161,0.0002422218,0.2289674,0.0001173468,0.0000432333,0.0006233943,0.00005365875,0.00005600658,0.6992638,0.00004118121,0.07002471,0.0002086107],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8896661,0.00009353471,0.0001615138,0.0007279121,0.000389688,0.0004332724,0.000002533007,0.00005655938,0.1084689],"genre_scores_gemma":[0.9759507,0.0001025521,0.0003562209,0.0002369119,0.0002284411,0.00002833669,0.000007226495,0.00002574683,0.02306384],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1015557,"threshold_uncertainty_score":0.5913168,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04225717038937385,"score_gpt":0.3623269281414317,"score_spread":0.3200697577520579,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}