{"id":"W2607232993","doi":"10.1016/j.celrep.2017.03.049","title":"Cooperativity Enables Non-neutralizing Antibodies to Neutralize Ebolavirus","year":2017,"lang":"en","type":"article","venue":"Cell Reports","topic":"Viral Infections and Outbreaks Research","field":"Medicine","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Public Health Agency of Canada","funders":"National Institute of Allergy and Infectious Diseases; U.S. Army; Defense Threat Reduction Agency; National Institutes of Health; Public Health Agency of Canada","keywords":"Neutralization; Antibody; Ebolavirus; Ebola virus; Neutralizing antibody; Virology; Monoclonal antibody; Cooperativity; IC50; Glycan; Potency; Biology; Chemistry; Virus; Glycoprotein; Immunology; Molecular biology; Cell culture; In vitro; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007496421,0.0003953205,0.0003698758,0.0001585768,0.0002636754,0.0005751462,0.0005870552,0.000468621,0.002696719],"category_scores_gemma":[0.0008213756,0.0003105104,0.000294315,0.0000840959,0.0004675,0.0004800349,0.0005467289,0.0007226181,0.0006088487],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004947171,"about_ca_system_score_gemma":0.0003125514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004688339,"about_ca_topic_score_gemma":0.001017765,"domain_scores_codex":[0.9992041,0.0001786183,0.00004347368,0.0001532847,0.0002230528,0.0001974846],"domain_scores_gemma":[0.9992466,0.0003457976,0.00009945632,0.0001160818,0.00008372154,0.0001083741],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001224048,0.00008139994,0.0006558286,0.00007455423,0.00002586038,0.00006351446,0.00003093871,0.0002377244,0.9944307,0.0008724827,0.0001556013,0.003248934],"study_design_scores_gemma":[0.00006925499,0.000948106,0.007199862,0.00001542078,0.00005781528,0.0005725755,0.00005784639,0.00462718,0.9790525,0.0008677108,0.006518341,0.0000135264],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9780207,0.002340089,0.009583825,0.000177382,0.00009838936,0.000118012,0.0001111891,0.0001497082,0.009400708],"genre_scores_gemma":[0.9962999,0.0002413655,0.00202878,0.0001026872,0.00001810649,0.00003731285,0.00006779791,0.00001052684,0.001193529],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002696719,"threshold_uncertainty_score":0.009021461,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04225717038937385,"score_gpt":0.3623269281414317,"score_spread":0.3200697577520579,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}