{"id":"W2607309430","doi":"10.1042/etls20160013","title":"Disarming the enemy: targeting bacterial toxins with small molecules","year":2017,"lang":"en","type":"article","venue":"Emerging Topics in Life Sciences","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Antitoxin; Microbiology; Vibrio cholerae; Antibiotics; Biology; Cholera toxin; Anthrax toxin; Toxin; Virulence; Pathogen; Antibiotic resistance; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002337381,0.0004522443,0.0004977031,0.0005118708,0.0001926163,0.0005515495,0.0002759781,0.0005715513,0.001608434],"category_scores_gemma":[0.0001460968,0.0001401714,0.0003885597,0.0003271321,0.0003470959,0.0007018169,0.0003539155,0.0009277058,0.000653343],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002609576,"about_ca_system_score_gemma":0.0002028606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004348116,"about_ca_topic_score_gemma":0.0008581149,"domain_scores_codex":[0.999917,0.00001663102,0.00000518629,0.00001498361,0.0000276905,0.00001846329],"domain_scores_gemma":[0.9999387,0.00001852433,0.00001374853,0.000002949622,0.00001394778,0.00001220054],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003922496,0.0004082531,0.0005102432,0.005156435,0.0001360152,0.0008959331,0.0001958389,0.001170708,0.5629088,0.009324916,0.005925216,0.4129755],"study_design_scores_gemma":[0.0002151733,0.005559528,0.003576309,0.0008739338,0.000309418,0.003395354,0.0002279755,0.002141202,0.3127429,0.00530791,0.6655552,0.00009515151],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.07097556,0.8807865,0.02558851,0.003256213,0.001072169,0.0001757087,0.000197914,0.0002388959,0.01770857],"genre_scores_gemma":[0.2021687,0.7659513,0.01559648,0.00212873,0.0005043591,0.000130208,0.000250131,0.00003150486,0.01323857],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001608434,"threshold_uncertainty_score":0.00538075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05855828575794277,"score_gpt":0.3348327573660781,"score_spread":0.2762744716081353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}