{"id":"W2607321425","doi":"10.1016/j.celrep.2017.03.053","title":"IDH1 Mutation Promotes Tumorigenesis by Inhibiting JNK Activation and Apoptosis Induced by Serum Starvation","year":2017,"lang":"en","type":"article","venue":"Cell Reports","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Ontario Institute for Cancer Research","funders":"Specialized Research Fund for the Doctoral Program of Higher Education of China; Fundamental Research Funds for the Central Universities; National Natural Science Foundation of China","keywords":"Carcinogenesis; Apoptosis; Kinase; Biology; Isocitrate dehydrogenase; Mutant; Cell biology; Cancer research; Molecular biology; Chemistry; Biochemistry; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001784119,0.0001387708,0.0001857364,0.00005649332,0.0003226761,0.0001096993,0.00002221955,0.00008230106,0.00001814167],"category_scores_gemma":[0.0002235097,0.0001235853,0.00003524106,0.00005146802,0.00002441412,0.0002734966,0.00002661095,0.00006455846,0.000002937837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008145006,"about_ca_system_score_gemma":0.00004000627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000322543,"about_ca_topic_score_gemma":0.000005115668,"domain_scores_codex":[0.9989781,0.00001602857,0.0002970241,0.0003244172,0.0002260463,0.0001583546],"domain_scores_gemma":[0.9989319,0.00003135028,0.0005467579,0.0002836857,0.0001099847,0.00009628733],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001082316,0.0002177791,0.1007028,0.00006649367,0.00002454382,0.00005276214,0.0001781742,3.864306e-7,0.8834869,0.000002558285,0.001294452,0.01396232],"study_design_scores_gemma":[0.0005328551,0.0001294866,0.07570019,0.00009751599,0.0000757062,0.0000403887,0.00008902333,0.00003889207,0.9228346,0.00008073208,0.0002757212,0.000104864],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972512,0.00008122813,0.00003599202,0.00108042,0.00009520972,0.0005072802,0.00000522763,0.00004249896,0.0009009143],"genre_scores_gemma":[0.9992309,0.0000270096,0.0001838728,0.00006181977,0.00005358735,0.00007092336,0.0002024955,0.00002207011,0.0001473892],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03934775,"threshold_uncertainty_score":0.5039663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01872479826288309,"score_gpt":0.2635085931358765,"score_spread":0.2447837948729935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}