{"id":"W2607349616","doi":"10.1016/j.immuni.2017.03.019","title":"Glutathione Primes T Cell Metabolism for Inflammation","year":2017,"lang":"en","type":"article","venue":"Immunity","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":515,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research; Deutsches Zentrum für Infektionsforschung; Center for Outcomes Research and Evaluation, Yale School of Medicine; National Multiple Sclerosis Society","keywords":"GCLC; GCLM; Glutathione; Biology; Cell biology; NFAT; PI3K/AKT/mTOR pathway; Glutaminolysis; T cell; Transcription factor; Biochemistry; Glycolysis; Signal transduction; Metabolism; Immunology; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002013965,0.000451472,0.0002736687,0.0002577905,0.0002914159,0.0007532674,0.0001393659,0.0006411493,0.005154058],"category_scores_gemma":[0.0001939117,0.0001573111,0.000326358,0.0001510569,0.0003973502,0.000597232,0.0006216061,0.0009477915,0.0007049856],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004141386,"about_ca_system_score_gemma":0.0004467642,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002043017,"about_ca_topic_score_gemma":0.0005033595,"domain_scores_codex":[0.99986,0.0000514565,0.00000620416,0.00002145672,0.00001708061,0.00004382117],"domain_scores_gemma":[0.9998989,0.00001222974,0.00001484067,0.00001536696,0.0000152358,0.00004333786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002583153,0.0001275999,0.001815977,0.0003134507,0.00005179635,0.0005465645,0.0001376807,0.0002361537,0.9610837,0.006644393,0.002273325,0.02418642],"study_design_scores_gemma":[0.000419084,0.004244728,0.02336222,0.0001621512,0.0002017633,0.001812701,0.0008086658,0.001167349,0.889802,0.01454024,0.06343787,0.00004135177],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.936925,0.03089111,0.007711213,0.008231261,0.001582117,0.00009687341,0.0006838372,0.0003908482,0.01348786],"genre_scores_gemma":[0.9882436,0.003843733,0.001618082,0.0004065457,0.0001531689,0.00002054817,0.0001776434,0.00002464391,0.005512008],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005154058,"threshold_uncertainty_score":0.01724201,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01853472843849572,"score_gpt":0.2761121081724895,"score_spread":0.2575773797339938,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}