{"id":"W2607381839","doi":"10.1016/j.jbspin.2017.04.003","title":"Monoclonal gammopathy of undetermined significance and biological treatments: What should we do?","year":2017,"lang":"en","type":"review","venue":"Joint Bone Spine","topic":"Bone health and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hôpital Notre-Dame","funders":"","keywords":"Medicine; Missense mutation; Minor allele frequency; Internal medicine; Genotype; Genetic testing; Genetic counseling; Allele; Osteoporosis; Compound heterozygosity; Mutation; Single-nucleotide polymorphism; Pediatrics; Genetics; Gene; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002462832,0.0006806492,0.00396419,0.0002404155,0.0001153621,0.00005704425,0.0001121418,0.000556924,0.00009958264],"category_scores_gemma":[0.0001223137,0.0004193055,0.0006073738,0.0001200714,0.00026762,0.0001482473,0.0001127988,0.000408553,0.00005335794],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002121336,"about_ca_system_score_gemma":0.0004657172,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001021261,"about_ca_topic_score_gemma":0.000007787355,"domain_scores_codex":[0.9972023,0.0001012228,0.001163362,0.0007522384,0.0003003427,0.000480553],"domain_scores_gemma":[0.9974906,0.00006367086,0.00101864,0.000894808,0.00007894242,0.0004533154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000832506,0.0004880411,0.0001002442,0.0100266,0.0003707779,0.0004917827,0.00001912696,7.35163e-9,0.000009277231,0.00005275975,0.0002001407,0.988158],"study_design_scores_gemma":[0.003029949,0.002723951,0.001762858,0.03352392,0.002351052,0.0007857623,0.0000171069,0.00000421058,0.00001883781,0.00009294608,0.9552767,0.0004126683],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005184275,0.9958633,0.000008220339,0.0007489085,0.0003007266,0.002090052,0.0001038969,0.00004980743,0.0003166813],"genre_scores_gemma":[0.0003929994,0.9952728,0.001180476,0.0001302111,0.0001778763,0.0002945296,0.0002988423,0.00005986379,0.002192437],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9877453,"threshold_uncertainty_score":0.9998259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3309761854778047,"score_gpt":0.4342655194037245,"score_spread":0.1032893339259198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}