{"id":"W2607381839","doi":"10.1016/j.jbspin.2017.04.003","title":"Monoclonal gammopathy of undetermined significance and biological treatments: What should we do?","year":2017,"lang":"en","type":"review","venue":"Joint Bone Spine","topic":"Bone health and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hôpital Notre-Dame","funders":"","keywords":"Medicine; Missense mutation; Minor allele frequency; Internal medicine; Genotype; Genetic testing; Genetic counseling; Allele; Osteoporosis; Compound heterozygosity; Mutation; Single-nucleotide polymorphism; Pediatrics; Genetics; Gene; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001968484,0.001058809,0.004454628,0.002529667,0.0004854542,0.002349284,0.001716579,0.003432991,0.004679874],"category_scores_gemma":[0.003262169,0.0005015489,0.001635998,0.002416516,0.0009749886,0.002977595,0.001045063,0.004086284,0.001130645],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001143762,"about_ca_system_score_gemma":0.003168526,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002711351,"about_ca_topic_score_gemma":0.008792547,"domain_scores_codex":[0.9992865,0.0001834444,0.0001570196,0.00009133467,0.0002229308,0.00005890293],"domain_scores_gemma":[0.998159,0.001120368,0.0003025526,0.00002875514,0.0002978883,0.00009147765],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002319988,0.0001075095,0.0005303993,0.07395409,0.0008190515,0.000290515,0.0001320113,0.0003908495,0.0003600379,0.004639528,0.06562927,0.8529148],"study_design_scores_gemma":[0.0001827524,0.0001573309,0.001917184,0.05947252,0.001853852,0.001519814,0.0003200999,0.0001721906,0.0001168352,0.004100994,0.9301214,0.00006491745],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00002363718,0.9990206,0.00002079602,0.0006131926,0.0001558906,0.000001665748,0.000007368566,0.000001415934,0.0001554251],"genre_scores_gemma":[0.0003694107,0.998206,0.0001038154,0.0008452952,0.0003266402,0.000004916983,0.00001448966,6.17237e-7,0.0001287869],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004679874,"threshold_uncertainty_score":0.01565582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3309761854778047,"score_gpt":0.4342655194037245,"score_spread":0.1032893339259198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}