{"id":"W2607406313","doi":"10.1083/jcb.2141oia135","title":"Targeting MTHFD2 in acute myeloid leukemia","year":2016,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"National Heart, Lung, and Blood Institute; Agios Pharmaceuticals; National Institute of Child Health and Human Development; Alex's Lemonade Stand Foundation for Childhood Cancer; Leukemia and Lymphoma Society; National Cancer Institute; CancerCare Manitoba Foundation","keywords":"Gene knockdown; Myeloid leukemia; Cancer research; Leukemia; Myeloid; Medicine; Biology; Immunology; Apoptosis; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003052421,0.0002868604,0.0003271636,0.0003004897,0.0001672938,0.0003263561,0.0002872139,0.0005471694,0.001514129],"category_scores_gemma":[0.0002168811,0.0001493725,0.000245508,0.0002798535,0.0002080989,0.0001927394,0.0002597388,0.001196829,0.0008232837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006350366,"about_ca_system_score_gemma":0.0003151048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005418029,"about_ca_topic_score_gemma":0.001000809,"domain_scores_codex":[0.9999046,0.00001440592,0.000008412426,0.00001765199,0.000033975,0.00002091696],"domain_scores_gemma":[0.9999398,0.000009106998,0.00001565677,0.000004535839,0.00001287614,0.00001808775],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00298312,0.000457007,0.003627779,0.002404471,0.0001532295,0.001545127,0.0001346371,0.00138992,0.4702104,0.007203988,0.03713884,0.4727516],"study_design_scores_gemma":[0.001263937,0.002587042,0.00920533,0.0003825271,0.0002814521,0.007624998,0.00007068166,0.002644505,0.1904797,0.00379955,0.7816186,0.00004171869],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.2351832,0.7125819,0.01475609,0.01402517,0.002089421,0.0002971071,0.001275663,0.000831779,0.01895964],"genre_scores_gemma":[0.6948895,0.2776397,0.008668846,0.003594712,0.0008855109,0.0002751426,0.001823385,0.0000564689,0.01216674],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001514129,"threshold_uncertainty_score":0.005065322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007732496175470703,"score_gpt":0.2458316711903204,"score_spread":0.2380991750148497,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}