{"id":"W2607454228","doi":"10.1016/j.jtho.2017.04.003","title":"Plasma ctDNA Analysis for Detection of the EGFR  T790M Mutation in Patients with Advanced Non–Small Cell Lung Cancer","year":2017,"lang":"en","type":"article","venue":"Journal of Thoracic Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":268,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital","funders":"Chugai Pharmaceutical; Pfizer; AstraZeneca; Ono Pharmaceutical; Bristol-Myers Squibb; Eli Lilly and Company; Astellas Pharma","keywords":"T790M; Osimertinib; Medicine; Lung cancer; Internal medicine; Oncology; Mutation; Cancer; Pathology; Adenocarcinoma; Biology; Gene; ROS1; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001595583,0.00008080254,0.000358703,0.000190322,0.0001151145,0.000009202663,0.0001048185,0.00007083864,0.00001215129],"category_scores_gemma":[0.00006892292,0.00004761134,0.0001444042,0.0001590166,0.00004319744,0.0001224139,0.00001431617,0.0001310168,2.084216e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005216429,"about_ca_system_score_gemma":0.0003911453,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001037835,"about_ca_topic_score_gemma":0.001221599,"domain_scores_codex":[0.9992743,0.00003792691,0.0003305282,0.0000973606,0.0001461084,0.0001138284],"domain_scores_gemma":[0.9981572,0.00006271469,0.001130381,0.0001822744,0.0004199939,0.00004744554],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003376027,0.0005352523,0.8443789,0.0001297769,0.001019213,0.00001250752,0.0009411701,0.004755001,0.001574277,0.000001426845,0.00002345425,0.143253],"study_design_scores_gemma":[0.004752571,0.001803975,0.9759082,0.0001326633,0.004494605,0.000007225307,0.0001952217,0.00129447,0.0110545,0.0000171947,0.0002865462,0.00005279549],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961193,0.00008895082,0.001979987,0.0005735296,0.0003983381,0.0005122651,0.00001615377,0.000001746035,0.0003097738],"genre_scores_gemma":[0.9974263,0.00002190055,0.002175122,0.00004766685,0.00006243046,0.00003562615,0.000004569002,0.000009371,0.0002170392],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1432002,"threshold_uncertainty_score":0.1941534,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01115495599980191,"score_gpt":0.4002118027229831,"score_spread":0.3890568467231811,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}