{"id":"W2607487047","doi":"10.1016/j.str.2017.03.007","title":"Structural Basis for Kinase-Mediated Macrolide Antibiotic Resistance","year":2017,"lang":"en","type":"article","venue":"Structure","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; McMaster University; McGill University; Canadian Light Source","keywords":"Phosphotransferase; Enzyme; Biochemistry; Chemistry; Transferase; Linker; GTP'; Phosphotransferases; Antibiotics; Stereochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001204865,0.0003416406,0.0003964065,0.0001344317,0.0004026633,0.0005418001,0.0004561311,0.0006429575,0.001296321],"category_scores_gemma":[0.000236559,0.0002516946,0.0002776188,0.00008549492,0.0005151908,0.0003277286,0.0001998867,0.0007687389,0.0008937322],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006534661,"about_ca_system_score_gemma":0.0003338967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003652653,"about_ca_topic_score_gemma":0.0003530717,"domain_scores_codex":[0.9999268,0.00001244773,0.000007434825,0.00002046613,0.00001745867,0.0000154765],"domain_scores_gemma":[0.9998966,0.00002388796,0.00002892307,0.00001603645,0.00001300241,0.00002141793],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001653941,0.00004487758,0.0002508187,0.0000654596,0.000008609652,0.0003482183,0.00003853306,0.002077305,0.986516,0.008513375,0.0001714761,0.00179992],"study_design_scores_gemma":[0.00005412726,0.000358038,0.003274465,0.000016374,0.00001966222,0.0007232491,0.00009668157,0.01460464,0.9711035,0.004076481,0.005643263,0.00002941221],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820562,0.00138941,0.009895715,0.0006125418,0.0001465801,0.00004302019,0.0001836931,0.0003013003,0.005371512],"genre_scores_gemma":[0.9970733,0.0002624742,0.00161495,0.0000817373,0.00001477247,0.00001235636,0.00009390901,0.00001345811,0.000833058],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001296321,"threshold_uncertainty_score":0.004741192,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01043712085424239,"score_gpt":0.2560394430296188,"score_spread":0.2456023221753764,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}