{"id":"W2607489624","doi":"10.1093/cvr/cvx064","title":"ULK1 prevents cardiac dysfunction in obesity through autophagy-meditated regulation of lipid metabolism","year":2017,"lang":"en","type":"article","venue":"Cardiovascular Research","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"Ewha Womans University; National Research Foundation","keywords":"Autophagy; Lipotoxicity; Endocrinology; Internal medicine; Lipoprotein lipase; Lipid metabolism; Cardiac function curve; MYH6; Adipose triglyceride lipase; Biology; Adipose tissue; Medicine; Cell biology; Heart failure; Lipolysis; Obesity; MYH7; Biochemistry; Insulin resistance","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003430199,0.0001723974,0.0008027837,0.0002485424,0.0003252347,0.000046494,0.0003211279,0.0002162123,0.0001290635],"category_scores_gemma":[0.0006981347,0.0001572641,0.0008921099,0.0003444063,0.0003503027,0.0003805226,0.0001617999,0.0004853679,0.000066625],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001587611,"about_ca_system_score_gemma":0.0002535155,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004356375,"about_ca_topic_score_gemma":0.000003225447,"domain_scores_codex":[0.9963736,0.0006675136,0.0003543702,0.000483218,0.001655915,0.0004653697],"domain_scores_gemma":[0.9970534,0.00007449506,0.0001007559,0.002104445,0.000514671,0.0001522081],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.007705703,0.005949012,0.2190306,0.005058622,0.04013851,0.001724461,0.008960607,0.001600109,0.2715317,0.008712702,0.02021413,0.4093738],"study_design_scores_gemma":[0.003155532,0.00009697113,0.8775668,0.0001969134,0.0002546474,0.000008744442,0.00008945644,0.0001549917,0.09734429,0.001492368,0.01950188,0.0001374133],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9793398,0.01244476,0.0002465377,0.0001210851,0.0006565232,0.001156928,0.00001517272,0.00004342631,0.005975801],"genre_scores_gemma":[0.9961017,0.001756564,0.0001827174,0.00001447757,0.0007607453,0.00009686672,0.00005974701,0.00003711025,0.0009901241],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6585362,"threshold_uncertainty_score":0.6413045,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0672252172690321,"score_gpt":0.3687944798798068,"score_spread":0.3015692626107747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}