{"id":"W2607628501","doi":"10.1158/1078-0432.ccr-17-0257","title":"Analytic, Preanalytic, and Clinical Validation of p53 IHC for Detection of <i>TP53</i> Missense Mutation in Prostate Cancer","year":2017,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"Genome British Columbia","funders":"Congressionally Directed Medical Research Programs; National Cancer Institute; National Institutes of Health","keywords":"Missense mutation; Prostate cancer; DU145; Biochemical recurrence; Cancer research; Immunohistochemistry; Prostate; Medicine; Prostatectomy; Pathology; Cancer; Immunostaining; Mutation; Biology; Oncology; Internal medicine; LNCaP; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004585979,0.0005413934,0.0002773262,0.0006084733,0.0003186229,0.0006458425,0.0005297609,0.0003993427,0.0006653719],"category_scores_gemma":[0.005695032,0.0002472315,0.0002288228,0.0002692485,0.0008748361,0.0002539353,0.0004555343,0.0004610482,0.0003730176],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003694376,"about_ca_system_score_gemma":0.0006423854,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008958358,"about_ca_topic_score_gemma":0.001413765,"domain_scores_codex":[0.9972845,0.0008022913,0.0002203551,0.0005748471,0.000985591,0.0001323116],"domain_scores_gemma":[0.9969985,0.0008968785,0.0005794395,0.0005349169,0.0008059649,0.0001843105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001919604,0.000540438,0.3453695,0.0002029202,0.0001796642,0.0004623546,0.0003251536,0.001677614,0.6113527,0.0002171649,0.000725535,0.03702731],"study_design_scores_gemma":[0.0001394768,0.004819662,0.5249597,0.00005708794,0.0003019983,0.004429569,0.0002240959,0.01021948,0.4510747,0.0002016301,0.003522873,0.00004961286],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9672101,0.001566095,0.02841902,0.0001327024,0.00005068404,0.0004378166,0.0002887588,0.0002832323,0.001611645],"genre_scores_gemma":[0.9877636,0.000215552,0.01102757,0.0001030743,0.00002404068,0.0001214898,0.000508773,0.00003112202,0.0002047236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004585979,"threshold_uncertainty_score":0.02425325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2974947797778756,"score_gpt":0.5982011123550526,"score_spread":0.3007063325771769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}