{"id":"W2607628501","doi":"10.1158/1078-0432.ccr-17-0257","title":"Analytic, Preanalytic, and Clinical Validation of p53 IHC for Detection of <i>TP53</i> Missense Mutation in Prostate Cancer","year":2017,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"Genome British Columbia","funders":"Congressionally Directed Medical Research Programs; National Cancer Institute; National Institutes of Health","keywords":"Missense mutation; Prostate cancer; DU145; Biochemical recurrence; Cancer research; Immunohistochemistry; Prostate; Medicine; Prostatectomy; Pathology; Cancer; Immunostaining; Mutation; Biology; Oncology; Internal medicine; LNCaP; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006662155,0.0001439632,0.0008712251,0.0003071227,0.0001817801,0.00005518046,0.0001927126,0.0002047207,0.00005208165],"category_scores_gemma":[0.004238577,0.0001115801,0.0002553432,0.0002859846,0.001175235,0.0002151222,0.0001272112,0.0006151946,0.000002248672],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001929688,"about_ca_system_score_gemma":0.0009659678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002459193,"about_ca_topic_score_gemma":0.001174736,"domain_scores_codex":[0.9965746,0.0004124823,0.001303309,0.0005654662,0.0007089404,0.0004351885],"domain_scores_gemma":[0.9955571,0.001669684,0.0004945664,0.0006021847,0.00142092,0.0002555597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01792695,0.0007649951,0.8110209,0.001133117,0.0004792615,0.00004822682,0.0002503198,0.00002350549,0.007856401,0.00003072036,0.0003573493,0.1601082],"study_design_scores_gemma":[0.02468762,0.004473949,0.821277,0.001348786,0.0005445262,0.000007881776,0.0004107739,0.007584236,0.1370868,0.001232489,0.001104702,0.0002412545],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927529,0.001674195,0.00003736451,0.002716107,0.0002205625,0.002248492,0.00007762729,0.000009471092,0.0002632535],"genre_scores_gemma":[0.986232,0.01169415,0.0001296462,0.00002551166,0.0002770809,0.0003396879,0.00002423117,0.00002705049,0.001250672],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.159867,"threshold_uncertainty_score":0.5074278,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2974947797778756,"score_gpt":0.5982011123550526,"score_spread":0.3007063325771769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}