{"id":"W2607652710","doi":"10.1073/pnas.1620774114","title":"Gestational bisphenol-A exposure lowers the threshold for autoimmunity in a model of multiple sclerosis","year":2017,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Reproductive System and Pregnancy","field":"Immunology and Microbiology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Innovates - Health Solutions","keywords":"Multiple sclerosis; Experimental autoimmune encephalomyelitis; Immunology; Bisphenol A; Medicine; Bisphenol; Pregnancy; Autoimmunity; Endocrine disruptor; Endocrine system; Endocrinology; Physiology; Internal medicine; Biology; Hormone; Immune system; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001813607,0.00007380301,0.0001625119,0.00007623249,0.0005057107,0.0000135383,0.001169833,0.00009822805,0.000006105281],"category_scores_gemma":[0.001128166,0.00004194154,0.00008267549,0.0001331157,0.001707289,0.0003306969,0.0001438149,0.00014146,6.115754e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001651794,"about_ca_system_score_gemma":0.00005365471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003209441,"about_ca_topic_score_gemma":7.940355e-7,"domain_scores_codex":[0.9991809,0.00001117589,0.0003163442,0.0001874563,0.0001794831,0.0001246458],"domain_scores_gemma":[0.9987859,0.0001941195,0.0006654938,0.00002843747,0.000321049,0.000005024457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00005101235,0.00006341944,0.09315817,0.0000685791,0.00003008925,4.094385e-10,0.0008888231,0.0009538363,0.8565119,0.04768513,0.0002621906,0.0003268517],"study_design_scores_gemma":[0.000587439,0.00005474296,0.5964751,0.0002301573,0.0000106712,0.000001712469,0.0003961576,0.000922979,0.3517047,0.04952125,0.00003141612,0.00006379012],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994096,0.0008708949,0.000005759793,0.002233073,0.00005217527,0.0003838849,0.00007429023,0.000003886067,0.002280035],"genre_scores_gemma":[0.9992175,0.00002360534,0.0003927116,0.0000341245,0.0000124317,0.00003668346,3.653682e-7,0.00000271531,0.0002799207],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5048072,"threshold_uncertainty_score":0.6290579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1305024878916087,"score_gpt":0.3107556753443094,"score_spread":0.1802531874527007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}