{"id":"W2607663437","doi":"10.1182/blood.v128.22.4241.4241","title":"Combined Targeting of STAT3 and STAT5: A Novel Approach to Overcome Drug Resistance in Ph+ Cml","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Ponatinib; Dasatinib; Nilotinib; Bosutinib; Imatinib; Cancer research; Imatinib mesylate; Tyrosine kinase; Myeloid leukemia; Medicine; Pharmacology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001254754,0.0002979514,0.0003741675,0.0003265734,0.0001258578,0.0003076542,0.0003332191,0.0002997821,0.001902209],"category_scores_gemma":[0.00004272983,0.0001041933,0.0004099737,0.0001883305,0.0001358111,0.0002697918,0.0003388051,0.0006837102,0.0004008901],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002621933,"about_ca_system_score_gemma":0.0001786699,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002707834,"about_ca_topic_score_gemma":0.0007130087,"domain_scores_codex":[0.9999413,0.000006082781,0.000003514895,0.00001222846,0.00001608039,0.00002075754],"domain_scores_gemma":[0.9999847,0.000001387188,0.000003740375,0.00000158817,0.000002425058,0.000006248521],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007332733,0.0005257551,0.0002866774,0.0004342137,0.00007286821,0.0001724268,0.00003660139,0.000885948,0.9372558,0.001190251,0.001232011,0.05717418],"study_design_scores_gemma":[0.001673,0.007621135,0.005655197,0.0001245869,0.0004641068,0.001399447,0.00009581744,0.01193699,0.8867913,0.001131856,0.08304066,0.00006586648],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9109788,0.04215765,0.03286159,0.001307851,0.0006431158,0.0005608195,0.0009558982,0.0007906485,0.009743659],"genre_scores_gemma":[0.9785744,0.008367344,0.007565915,0.0004254301,0.00005676097,0.0001580305,0.0005254186,0.00002742918,0.004299248],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001902209,"threshold_uncertainty_score":0.006363571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01229047656741036,"score_gpt":0.2382235188245373,"score_spread":0.2259330422571269,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}