{"id":"W2607727609","doi":"10.3390/v9040090","title":"Replication and Oncolytic Activity of an Avian Orthoreovirus in Human Hepatocellular Carcinoma Cells","year":2017,"lang":"en","type":"article","venue":"Viruses","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Toronto General Hospital; University of Guelph","funders":"Ministry of Agriculture, Food and Rural Affairs; Natural Sciences and Engineering Research Council of Canada; Ontario Ministry of Agriculture, Food and Rural Affairs","keywords":"Oncolytic virus; Virology; Hepatocellular carcinoma; Biology; Virus; Interferon; Viral replication; Hepatitis C virus; Cytolysis; Cancer research; Cytotoxic T cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001503085,0.0002280366,0.0001697102,0.0001474772,0.0001445492,0.0002117401,0.0001095594,0.0001576174,0.0007084635],"category_scores_gemma":[0.0001141152,0.0001097771,0.0003242735,0.0001194455,0.0001115211,0.0001166435,0.00009176513,0.0001864495,0.0002486546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003458213,"about_ca_system_score_gemma":0.0002373278,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00691796,"about_ca_topic_score_gemma":0.005031316,"domain_scores_codex":[0.9999309,0.00001864022,0.000004448637,0.00001243864,0.0000205791,0.00001298119],"domain_scores_gemma":[0.9999566,0.000014202,0.000007052914,0.000008470263,0.000007578299,0.000006114707],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001778656,0.00005595412,0.0008193752,0.0001061374,0.00001853416,0.000106663,0.00006523944,0.006743407,0.9885514,0.0004120319,0.00007867119,0.002864845],"study_design_scores_gemma":[0.00003156647,0.0007850557,0.00374269,0.00001245768,0.00003450811,0.0002175085,0.00006706711,0.02782196,0.964111,0.000122314,0.003039124,0.00001486175],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951985,0.0008703364,0.002308954,0.00002423668,0.000008983869,0.00001465209,0.0002193747,0.00003094861,0.001323973],"genre_scores_gemma":[0.9957287,0.000459673,0.002612659,0.000005882178,0.000001451146,0.000009697167,0.0004247767,0.000008246942,0.0007489864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00691796,"threshold_uncertainty_score":0.01375538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04901558752989468,"score_gpt":0.3500905362348921,"score_spread":0.3010749487049974,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}