{"id":"W2607785336","doi":"10.1001/jamaoncol.2017.0502","title":"Association Between <i>SLC16A5</i> Genetic Variation and Cisplatin-Induced Ototoxic Effects in Adult Patients With Testicular Cancer","year":2017,"lang":"en","type":"article","venue":"JAMA Oncology","topic":"Hearing, Cochlea, Tinnitus, Genetics","field":"Neuroscience","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; BC Cancer Agency; Princess Margaret Cancer Centre; University of Toronto; BC Children's Hospital; University Health Network; University of British Columbia","funders":"","keywords":"Medicine; Testicular cancer; Interquartile range; Cisplatin; Pharmacogenomics; Internal medicine; Oncology; Odds ratio; Ototoxicity; Chemotherapy; Cancer; Pharmacogenetics; Bioinformatics; Genotype; Pharmacology; Genetics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002951394,0.0001920909,0.0003349016,0.0001106941,0.0002875115,0.0001441619,0.0002741905,0.0003525694,0.0000105245],"category_scores_gemma":[0.00636273,0.0001834958,0.00002269878,0.0001471307,0.00006988159,0.0002036912,0.000157166,0.0003656746,0.00002622785],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005485748,"about_ca_system_score_gemma":0.0002016844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005454489,"about_ca_topic_score_gemma":0.0006255416,"domain_scores_codex":[0.997965,0.0003635698,0.0003179196,0.0005281771,0.0003782402,0.0004470329],"domain_scores_gemma":[0.997732,0.0009778737,0.0005888238,0.0004023494,0.0001726178,0.0001263199],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00003951958,0.00009697743,0.9350018,0.00003794002,0.00001318739,0.0000256838,0.0004435852,0.00005418006,0.04274465,0.00002171623,0.00005406262,0.02146669],"study_design_scores_gemma":[0.00347565,0.0006509741,0.9781095,0.00006835034,0.00006678593,0.000002267829,0.00000335311,0.0008015897,0.01614064,0.000151558,0.0003227668,0.0002065086],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972068,0.000008914873,0.0001375199,0.0008593604,0.0003159299,0.0008453944,0.00001535637,0.00003404731,0.0005766919],"genre_scores_gemma":[0.9973243,0.00002591621,0.001368589,0.0008572232,0.0001973833,0.0001192602,0.000003789367,0.00003118587,0.00007231011],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04310776,"threshold_uncertainty_score":0.7617242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01883450593665139,"score_gpt":0.2915562990653328,"score_spread":0.2727217931286814,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}