{"id":"W2607808741","doi":"10.1002/path.4912","title":"The histone methyltransferase <scp>EZH2</scp> is a therapeutic target in small cell carcinoma of the ovary, hypercalcaemic type","year":2017,"lang":"en","type":"article","venue":"The Journal of Pathology","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia; BC Cancer Agency","funders":"National Cancer Institute; Korea National Institute of Health; Canadian Cancer Society Research Institute","keywords":"EZH2; Ovary; Cancer research; Ovarian carcinoma; Histone; Methyltransferase; Cell biology; Chemistry; Biology; Medicine; Methylation; Internal medicine; Biochemistry; Cancer; Ovarian cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008748966,0.0001438881,0.0002104466,0.0001923019,0.0001240619,0.0001797628,0.0001276043,0.0002182751,0.001021104],"category_scores_gemma":[0.0001091039,0.0000624503,0.0001289201,0.0002135379,0.0001623706,0.000132128,0.000125577,0.0003369806,0.000188013],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002824571,"about_ca_system_score_gemma":0.0001691278,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005727518,"about_ca_topic_score_gemma":0.001408091,"domain_scores_codex":[0.9999499,0.000005103229,0.000003986634,0.000008660659,0.00002074038,0.00001168217],"domain_scores_gemma":[0.9999713,0.000004881589,0.000007322844,0.000003516432,0.000005311614,0.000007681355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004942394,0.0000443542,0.002792449,0.0002039509,0.00003391498,0.0006611533,0.00002837123,0.0002716529,0.9568155,0.000311686,0.0009236265,0.03741924],"study_design_scores_gemma":[0.0001727683,0.0009370634,0.0325025,0.00001810951,0.00009458874,0.004986826,0.00008418049,0.001244129,0.9175012,0.000303993,0.0421446,0.00001001729],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9689905,0.02113107,0.002405972,0.001074569,0.000106837,0.00006549816,0.0003702004,0.0001695738,0.005685711],"genre_scores_gemma":[0.9923049,0.004093784,0.0008198569,0.0001447604,0.00003488676,0.00002359642,0.0003631368,0.00001061446,0.002204475],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001021104,"threshold_uncertainty_score":0.003416002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02036927190941561,"score_gpt":0.2747584057493719,"score_spread":0.2543891338399563,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}