{"id":"W2607859402","doi":"10.1093/sleepj/zsx050.674","title":"0675 A RANDOMIZED, PLACEBO-CONTROLLED, PHASE 3 STUDY OF THE SAFETY AND EFFICACY OF JZP-110 FOR THE TREATMENT OF EXCESSIVE SLEEPINESS IN PATIENTS WITH NARCOLEPSY","year":2017,"lang":"en","type":"article","venue":"SLEEP","topic":"Sleep and Wakefulness Research","field":"Neuroscience","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Narcolepsy; Epworth Sleepiness Scale; Medicine; Placebo; Clinical endpoint; Cataplexy; Modafinil; Adverse effect; Population; Randomized controlled trial; Sleep disorder; Wakefulness; Somnolence; Excessive daytime sleepiness; Internal medicine; Physical therapy; Psychology; Polysomnography; Psychiatry; Insomnia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005496315,0.0001738822,0.0008120809,0.00008670169,0.0003324672,0.00002967875,0.0005753729,0.00003832069,0.00001209309],"category_scores_gemma":[0.001590888,0.0000755733,0.0001482073,0.0001451218,0.0006628556,0.00009755287,0.0001045586,0.00007530762,3.141556e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002787291,"about_ca_system_score_gemma":0.00003855294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002098,"about_ca_topic_score_gemma":0.0001108062,"domain_scores_codex":[0.9980333,0.0004456951,0.0004915727,0.0003054283,0.0004922879,0.0002316505],"domain_scores_gemma":[0.9959596,0.002443885,0.0006127613,0.0007887426,0.0001521253,0.00004287834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8947508,0.01059582,0.03374554,0.00004974096,0.000266572,0.000003582026,0.005238065,0.0004316035,0.0004174939,0.0001686878,0.00000303167,0.05432908],"study_design_scores_gemma":[0.9384775,0.002702856,0.04447492,0.00005463604,0.0002417741,4.049164e-7,0.0004626206,0.002572139,0.0108398,0.00004219658,0.00003056721,0.00010057],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903839,0.00008133904,0.0001275577,0.0001512373,0.0001301286,0.008908025,0.00006353284,0.000003691906,0.0001506134],"genre_scores_gemma":[0.9991946,0.00003676835,0.000006940815,0.000008971447,0.00001915104,0.0006524221,9.476403e-7,0.00001432327,0.00006582963],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05422851,"threshold_uncertainty_score":0.308179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02404656389669357,"score_gpt":0.3197162130426724,"score_spread":0.2956696491459788,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}