{"id":"W2607899612","doi":"","title":"The Wnt5a-β-catenin Pathway Triggers a Metabolic Switch That Drives Indoleamine 2,3-dioxygenase Activity and Dendritic Cell Tolerization in the Melanoma Microenvironment.","year":2017,"lang":"en","type":"article","venue":"DukeSpace (Duke University)","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Cancer Institute; Kite Pharma; Cancer Institute, University of Pittsburgh; Oregon Clinical and Translational Research Institute; Deutsches Zentrum für Lungenforschung; National Institutes of Health; M.J. Murdock Charitable Trust; Terry Fox Foundation; University of Pittsburgh; Midwest Athletes Against Childhood Cancer; National Institute of Allergy and Infectious Diseases; Dr. Miriam and Sheldon G. Adelson Medical Research Foundation; Harry J. Lloyd Charitable Trust; Achievement Rewards for College Scientists Foundation; Dana-Farber/Harvard Cancer Center; National Science Foundation","keywords":"Indoleamine 2,3-dioxygenase; Melanoma; WNT5A; Cancer research; Catenin; Metabolic pathway; Tumor microenvironment; Biology; Chemistry; Medicine; Wnt signaling pathway; Cell biology; Signal transduction; Tumor cells; Gene; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004977407,0.0001570704,0.000109765,0.0001555739,0.0002038207,0.0003792768,0.0001150528,0.0002234941,0.00313995],"category_scores_gemma":[0.00007365846,0.0001105918,0.000165016,0.0001043595,0.0001436353,0.0001897154,0.0002689442,0.0004622353,0.0005663583],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004729248,"about_ca_system_score_gemma":0.0003353794,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001580047,"about_ca_topic_score_gemma":0.004163839,"domain_scores_codex":[0.9999001,0.000009195828,0.000004122698,0.00002085645,0.00002238106,0.00004325363],"domain_scores_gemma":[0.9999566,0.000003172846,0.00001365561,0.000003678302,0.00000541069,0.00001746847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001257326,0.00001487235,0.0002996528,0.00001434552,0.000002938695,0.0001221876,0.00001378683,0.00003598048,0.997326,0.0004598152,0.0002299216,0.001354732],"study_design_scores_gemma":[0.00005022847,0.000248477,0.02479794,0.00002244035,0.00001820783,0.0007478924,0.0002595869,0.001822053,0.9606212,0.0006482896,0.01075085,0.00001281868],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859377,0.001639103,0.002384051,0.0004693531,0.0001472954,0.00002785044,0.0006031941,0.0001129178,0.008678654],"genre_scores_gemma":[0.9947232,0.0004767463,0.0007698608,0.00007473471,0.000006937888,0.00001264787,0.0002210601,0.00001302778,0.003701672],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00313995,"threshold_uncertainty_score":0.01050413,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01585560647905137,"score_gpt":0.2001780803875166,"score_spread":0.1843224739084652,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}