{"id":"W2607899612","doi":"","title":"The Wnt5a-β-catenin Pathway Triggers a Metabolic Switch That Drives Indoleamine 2,3-dioxygenase Activity and Dendritic Cell Tolerization in the Melanoma Microenvironment.","year":2017,"lang":"en","type":"article","venue":"DukeSpace (Duke University)","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Cancer Institute; Kite Pharma; Cancer Institute, University of Pittsburgh; Oregon Clinical and Translational Research Institute; Deutsches Zentrum für Lungenforschung; National Institutes of Health; M.J. Murdock Charitable Trust; Terry Fox Foundation; University of Pittsburgh; Midwest Athletes Against Childhood Cancer; National Institute of Allergy and Infectious Diseases; Dr. Miriam and Sheldon G. Adelson Medical Research Foundation; Harry J. Lloyd Charitable Trust; Achievement Rewards for College Scientists Foundation; Dana-Farber/Harvard Cancer Center; National Science Foundation","keywords":"Indoleamine 2,3-dioxygenase; Melanoma; WNT5A; Cancer research; Catenin; Metabolic pathway; Tumor microenvironment; Biology; Chemistry; Medicine; Wnt signaling pathway; Cell biology; Signal transduction; Tumor cells; Gene; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.0002046195,0.0002233617,0.0001964932,0.0001737646,0.001746751,0.0002568129,0.0009495564,0.00008865472,0.00001183808],"category_scores_gemma":[0.0001519602,0.0001635524,0.00008033223,0.0002175041,0.000555289,0.0005346367,0.0004052069,0.0002576475,0.00001537254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005258647,"about_ca_system_score_gemma":0.00005179858,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001047142,"about_ca_topic_score_gemma":0.0005263913,"domain_scores_codex":[0.9984012,0.0003777118,0.00009119451,0.0004649708,0.0002712428,0.0003937055],"domain_scores_gemma":[0.9987625,0.0003488805,0.000194459,0.0005942534,0.00001010479,0.00008977589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001935641,0.0002074858,0.002916274,0.00001961794,0.00001173258,0.0002269722,0.002933963,0.00001947625,0.9843127,0.003808763,0.0001026697,0.005246844],"study_design_scores_gemma":[0.002199977,0.00007642839,0.07538075,0.00001927466,0.00001832882,0.00001519599,0.004068265,0.000232642,0.8571962,0.00007413913,0.06040977,0.0003090675],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919837,0.0002884151,0.0001296381,0.002284979,0.00009451631,0.0004070007,0.00001512791,0.00003052568,0.004766114],"genre_scores_gemma":[0.9948599,0.001420132,0.00002077288,0.0001569379,0.00002136891,0.000003056692,0.00000178157,0.00001653888,0.003499531],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1271165,"threshold_uncertainty_score":0.9995528,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01585560647905137,"score_gpt":0.2001780803875166,"score_spread":0.1843224739084652,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}