{"id":"W2607943367","doi":"10.1007/s00401-017-1713-y","title":"DNA methylation age-acceleration is associated with disease duration and age at onset in C9orf72 patients","year":2017,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ted Rogers Centre for Heart Research; Sunnybrook Health Science Centre; Toronto Western Hospital; Canada Research Chairs; University of Toronto; University Health Network; Health Sciences Centre; Occupational Cancer Research Centre","funders":"Temerty Family Foundation; Consortium canadien en neurodégénérescence associée au vieillissement; Alzheimer Society; Fondation Brain Canada; ALS Society of Canada","keywords":"C9orf72; Duration (music); Medicine; DNA methylation; Age of onset; Disease; Biology; Internal medicine; Oncology; Physiology; Genetics; Dementia; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000931656,0.000137305,0.0001022631,0.0000299185,0.0002642816,0.00008496288,0.000120116,0.00007037497,0.000007858831],"category_scores_gemma":[0.0003428102,0.0001181584,0.00002145883,0.00003162906,0.00008535492,0.00001211054,0.0001631022,0.00005774855,0.000002380488],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001238989,"about_ca_system_score_gemma":0.00001444821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000313979,"about_ca_topic_score_gemma":0.00009665792,"domain_scores_codex":[0.9990968,0.00009547501,0.0001657107,0.0003768887,0.0001114091,0.0001537767],"domain_scores_gemma":[0.9994483,0.000008441473,0.0001706465,0.0002740553,0.0000356731,0.00006285634],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002041409,0.0001399733,0.3541471,0.000005968042,0.000006828916,0.0001178768,0.00009965351,0.000006354433,0.6438419,0.000002208071,0.0003180183,0.001109928],"study_design_scores_gemma":[0.0006681911,0.0002708849,0.9825227,0.00000753708,0.000009530563,0.000002324775,0.000004241775,0.00002870368,0.01582256,0.00003825543,0.0004775178,0.0001475395],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990413,0.00002269323,0.000008630281,0.0002775327,0.00005012536,0.0002333963,0.000031068,0.000008280877,0.0003270333],"genre_scores_gemma":[0.9984785,0.0001917362,0.00005486741,0.0005172828,0.000006150767,0.00002058951,0.0004798266,0.00001526216,0.0002358101],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6283756,"threshold_uncertainty_score":0.4818361,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0175328234314575,"score_gpt":0.2362199562310984,"score_spread":0.2186871327996409,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}