{"id":"W2607943367","doi":"10.1007/s00401-017-1713-y","title":"DNA methylation age-acceleration is associated with disease duration and age at onset in C9orf72 patients","year":2017,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ted Rogers Centre for Heart Research; Sunnybrook Health Science Centre; Toronto Western Hospital; Canada Research Chairs; University of Toronto; University Health Network; Health Sciences Centre; Occupational Cancer Research Centre","funders":"Temerty Family Foundation; Consortium canadien en neurodégénérescence associée au vieillissement; Alzheimer Society; Fondation Brain Canada; ALS Society of Canada","keywords":"C9orf72; Duration (music); Medicine; DNA methylation; Age of onset; Disease; Biology; Internal medicine; Oncology; Physiology; Genetics; Dementia; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001967047,0.0002506256,0.0003065472,0.0007716538,0.0002685515,0.0002340229,0.0001550631,0.0004469161,0.002561816],"category_scores_gemma":[0.001145235,0.0001480842,0.0002615983,0.0006589901,0.0001229127,0.0001645918,0.0001967186,0.0003171267,0.0002992478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001667973,"about_ca_system_score_gemma":0.0001105815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002249209,"about_ca_topic_score_gemma":0.002045935,"domain_scores_codex":[0.9998649,0.00002282705,0.00001673661,0.0000515486,0.00002004533,0.00002399137],"domain_scores_gemma":[0.9992011,0.0001228583,0.0004029549,0.00004461243,0.00008179479,0.0001466282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007818815,0.00002691984,0.9839116,0.00002097639,0.00007852135,0.0004425717,0.0001154293,0.00007393915,0.009985665,0.00002286826,0.0001299065,0.004409732],"study_design_scores_gemma":[0.000004379221,0.00006534065,0.9986473,0.000002915277,0.00002285325,0.0006160595,0.00002424531,0.0001260357,0.0003186449,0.00002569575,0.0001434972,0.00000313311],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989507,0.0003355431,0.0001156992,0.00002571435,0.000003976016,0.000004773854,0.0002422042,0.000008940638,0.0003124498],"genre_scores_gemma":[0.9993725,0.00008102717,0.00008687087,0.00001151983,0.000007179804,0.000003830529,0.0002010963,0.000002731185,0.0002332531],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002561816,"threshold_uncertainty_score":0.008570075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0175328234314575,"score_gpt":0.2362199562310984,"score_spread":0.2186871327996409,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}