{"id":"W2607944311","doi":"10.1038/leu.2017.122","title":"Efficacy and safety of carfilzomib regimens in multiple myeloma patients relapsing after autologous stem cell transplant: ASPIRE and ENDEAVOR outcomes","year":2017,"lang":"en","type":"article","venue":"Leukemia","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Leukemia & Lymphoma Society of Canada","funders":"Onyx Pharmaceuticals; Amgen","keywords":"Carfilzomib; Lenalidomide; Medicine; Autologous stem-cell transplantation; Multiple myeloma; Oncology; Internal medicine; Dexamethasone; Bortezomib; Hazard ratio; Salvage therapy; Transplantation; Chemotherapy; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00218328,0.0002775423,0.001166558,0.0005080168,0.0002228073,0.0008117154,0.0002668623,0.0004346989,0.0006668555],"category_scores_gemma":[0.002172498,0.0001170696,0.001758048,0.0005480392,0.0003576511,0.0006181161,0.000530461,0.0006629482,0.0001228817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000754807,"about_ca_system_score_gemma":0.0005734852,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008984065,"about_ca_topic_score_gemma":0.002081692,"domain_scores_codex":[0.9990663,0.000264392,0.00009732394,0.000150288,0.0002311065,0.0001906785],"domain_scores_gemma":[0.9986082,0.0003264012,0.0005891453,0.000092997,0.00009361812,0.000289728],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2174901,0.002878511,0.5657181,0.0005372212,0.005978892,0.0003862594,0.0003309958,0.003304768,0.004170568,0.0003538993,0.001637889,0.1972128],"study_design_scores_gemma":[0.009098283,0.0611853,0.91797,0.0001067218,0.00248666,0.0007819235,0.0002245247,0.002728998,0.001834629,0.0006379623,0.00289622,0.00004876421],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957519,0.003068271,0.00006616059,0.0001296401,0.000009689091,0.00003196496,0.000328115,0.000007377535,0.0006068299],"genre_scores_gemma":[0.9987429,0.0003581104,0.00004088985,0.00009514704,0.00002994169,0.00001454886,0.0005993245,0.00000136974,0.0001178516],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00218328,"threshold_uncertainty_score":0.01154637,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01937783906273831,"score_gpt":0.2684230750100851,"score_spread":0.2490452359473468,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}