{"id":"W2607978114","doi":"10.1016/j.cytogfr.2017.04.004","title":"Impairment of the type I interferon response by HIV-1: Potential targets for HIV eradication","year":2017,"lang":"en","type":"review","venue":"Cytokine & Growth Factor Reviews","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"","keywords":"Interferon; Downregulation and upregulation; Biology; Virology; SAMHD1; Human immunodeficiency virus (HIV); Signalling; Interferon type I; Receptor; Virus; In vitro; Immunology; Cell biology; Gene; RNA; Genetics; Reverse transcriptase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0008248956,0.0005878194,0.002318026,0.0001386202,0.0003192436,0.00003257293,0.001167862,0.0004424889,0.0005151217],"category_scores_gemma":[0.0008518416,0.0003230507,0.001222706,0.0001321458,0.0002721138,0.00007618644,0.0002636104,0.0005056862,0.001853269],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002782364,"about_ca_system_score_gemma":0.0003984294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001382744,"about_ca_topic_score_gemma":0.000002422469,"domain_scores_codex":[0.9961339,0.001539195,0.001116093,0.0005805292,0.00009115136,0.0005391378],"domain_scores_gemma":[0.996893,0.0002542212,0.00132262,0.001302458,0.0001579737,0.00006973856],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009641708,0.0004745955,0.00005478181,0.00957046,0.0009480027,0.000003679757,0.00008838798,1.372945e-8,0.002177029,0.00002796184,0.3285206,0.6571703],"study_design_scores_gemma":[0.0009918663,0.0006642005,0.00009525242,0.004144592,0.0006111039,0.00002631949,0.000001980726,9.583159e-8,0.0005813744,0.000006592938,0.9926165,0.0002601644],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008112525,0.9890399,0.0001180749,0.000319151,0.0007312193,0.004892004,0.004738221,0.00002321565,0.00005709127],"genre_scores_gemma":[0.0006239598,0.9877113,0.00004443859,0.00002621517,0.00006579432,0.000772888,0.004046061,0.00005830444,0.006651082],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6640958,"threshold_uncertainty_score":0.9999222,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06571065734904999,"score_gpt":0.3586416021046773,"score_spread":0.2929309447556273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}