{"id":"W2607980041","doi":"10.3233/jad-170164","title":"Quantification of Butyrylcholinesterase Activity as a Sensitive and Specific Biomarker of Alzheimer’s Disease","year":2017,"lang":"en","type":"article","venue":"Journal of Alzheimer s Disease","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Saint Vincent University; Dalhousie University","funders":"Canadian Institutes of Health Research; Dalhousie University; Nova Scotia Health Research Foundation; Dalhousie Medical Research Foundation","keywords":"Butyrylcholinesterase; Biomarker; Disease; Alzheimer's disease; Medicine; Neuroscience; Biology; Acetylcholinesterase; Internal medicine; Aché; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00028984,0.0002898051,0.0007067657,0.0002913198,0.0001612529,0.00006412218,0.0001634829,0.00005723855,0.00005863761],"category_scores_gemma":[0.0005410339,0.0002358318,0.0004517196,0.0001058131,0.0004572086,0.000608458,0.00008866689,0.0001832835,0.000006365671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001395809,"about_ca_system_score_gemma":0.0004541336,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002339455,"about_ca_topic_score_gemma":0.000001315594,"domain_scores_codex":[0.9979487,0.0001609497,0.0007698223,0.000337207,0.0005752634,0.0002080347],"domain_scores_gemma":[0.9955115,0.0001048344,0.001529391,0.0008308379,0.0009810814,0.001042359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.04143029,0.006928504,0.2200087,0.0005168375,0.003969838,0.003953728,0.000543602,0.00003919545,0.6868057,0.0002876004,0.002883535,0.0326325],"study_design_scores_gemma":[0.002416542,0.0001938933,0.8428017,0.0004184867,0.004296372,0.0000746549,0.00004794517,0.000199296,0.1491093,0.00005908658,0.0001976832,0.00018495],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849769,0.01223391,0.00007188234,0.001705369,0.000260659,0.0004094897,0.0002646276,0.000008632139,0.00006848034],"genre_scores_gemma":[0.9982886,0.001019369,0.0001131133,0.0001958093,0.0002936893,0.000005309379,0.00002536149,0.00003561484,0.00002312487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6227931,"threshold_uncertainty_score":0.961694,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09676233877570185,"score_gpt":0.3639690319512239,"score_spread":0.2672066931755221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}