{"id":"W2608108963","doi":"10.1038/nmicrobiol.2017.61","title":"Antimicrobials: Expressing antibiotic gene clusters","year":2017,"lang":"en","type":"letter","venue":"Nature Microbiology","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Gene; Drug discovery; Antibiotics; Antimicrobial; Computational biology; Biology; Microbiology; Genetics; Bioinformatics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.0003594414,0.0009382174,0.001857975,0.0004594909,0.0004337447,0.0001655715,0.0009365104,0.009116072,0.0003445944],"category_scores_gemma":[0.0004764895,0.0007030724,0.0006215949,0.0001347887,0.0006817651,0.0001021275,0.0003845616,0.009102389,0.0003308103],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002063078,"about_ca_system_score_gemma":0.000309138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003444199,"about_ca_topic_score_gemma":0.000004921656,"domain_scores_codex":[0.9961737,0.0002372047,0.0006484825,0.00163617,0.0001414709,0.001162976],"domain_scores_gemma":[0.9967835,0.0001417503,0.0007619442,0.001866615,0.0003379059,0.000108286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006728523,0.00002608988,0.00001014748,0.0003343432,0.0002009613,0.001117351,0.00001119303,5.350107e-8,0.4896331,4.979419e-7,0.5077973,0.0008017073],"study_design_scores_gemma":[0.0005715492,0.00008547446,0.0000221979,0.0005980472,0.0003722608,0.004242468,0.000001692501,5.753802e-7,0.3667724,0.00000437222,0.6268267,0.000502286],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.02071098,0.01296984,0.000007859004,0.9546901,0.006798982,0.001366092,0.0009941036,0.000265912,0.002196133],"genre_scores_gemma":[0.06456481,0.0005497312,0.003466184,0.8883902,0.01737924,0.000001068837,0.005606946,0.0002306534,0.01981115],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.1228607,"threshold_uncertainty_score":0.9995421,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01570999208740715,"score_gpt":0.269738091656865,"score_spread":0.2540280995694578,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}