{"id":"W2608211931","doi":"10.1158/2159-8290.cd-17-0146","title":"Analysis of Circulating Cell-Free DNA Identifies Multiclonal Heterogeneity of <i>BRCA2</i> Reversion Mutations Associated with Resistance to PARP Inhibitors","year":2017,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":268,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Cancer Institute; Cancer Research UK","keywords":"Reversion; DNA; Mutation; Poly ADP ribose polymerase; DNA damage; Biology; Chemistry; Cancer research; Genetics; Gene; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002073002,0.0001902582,0.0001704393,0.0007509374,0.0001445282,0.0003955876,0.0002145442,0.0005852939,0.002224048],"category_scores_gemma":[0.0005538867,0.0001298727,0.0001107723,0.0002618169,0.0002934705,0.000168728,0.0002317043,0.0004706918,0.0005217741],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003118389,"about_ca_system_score_gemma":0.0001187004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007115426,"about_ca_topic_score_gemma":0.0009866195,"domain_scores_codex":[0.9998053,0.00002431274,0.00001501248,0.00007249262,0.00005330209,0.00002959962],"domain_scores_gemma":[0.999602,0.0001382356,0.00009119672,0.00004383113,0.00006765289,0.00005704774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005378469,0.00004839263,0.03600156,0.0001060014,0.00004230624,0.00124654,0.0001327707,0.0001666757,0.9269184,0.0002693236,0.00172205,0.03280809],"study_design_scores_gemma":[0.0001352733,0.001122414,0.2773281,0.00009141658,0.000133447,0.02993703,0.0002978479,0.003658442,0.6623254,0.001330306,0.02359164,0.00004877983],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9711096,0.007163879,0.01291959,0.001601017,0.0001989758,0.00009358353,0.00205039,0.0004688108,0.004394098],"genre_scores_gemma":[0.9917374,0.001102391,0.00400035,0.0006091278,0.0000690016,0.00003424777,0.000793167,0.00004752439,0.001606685],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002224048,"threshold_uncertainty_score":0.007440209,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02755752012958285,"score_gpt":0.3162239602348135,"score_spread":0.2886664401052306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}