{"id":"W2608357984","doi":"10.3390/cancers9050040","title":"HER2 in Breast Cancer Stemness: A Negative Feedback Loop towards Trastuzumab Resistance","year":2017,"lang":"en","type":"review","venue":"Cancers","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"University of Alberta; Women and Children's Health Research Institute; Children's Health Research Institute","keywords":"Lapatinib; Trastuzumab; Cancer research; Cancer stem cell; Medicine; Epithelial–mesenchymal transition; Wnt signaling pathway; Breast cancer; Tumor microenvironment; Cancer; Biology; Internal medicine; Metastasis; Signal transduction; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003641232,0.0003294315,0.0003529719,0.0002888972,0.000241409,0.0009012617,0.0003460647,0.0004652854,0.003035762],"category_scores_gemma":[0.0005455875,0.0001503693,0.0002188555,0.0001978021,0.0003212227,0.0004227071,0.000458996,0.000809307,0.0008482432],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000709939,"about_ca_system_score_gemma":0.0002595499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003330841,"about_ca_topic_score_gemma":0.0004407453,"domain_scores_codex":[0.9997461,0.00004964417,0.00001308543,0.00004109489,0.00008953122,0.00006045029],"domain_scores_gemma":[0.9997812,0.00003704849,0.00005766847,0.00001355229,0.00005626628,0.00005431083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001550804,0.0004429478,0.01995716,0.0009957714,0.0001168467,0.00286064,0.0006824301,0.001947724,0.6857538,0.01160089,0.02518615,0.2489048],"study_design_scores_gemma":[0.0006699812,0.003401501,0.0901342,0.0004315439,0.0004327531,0.01273841,0.00107081,0.01602038,0.5052316,0.02503438,0.3447042,0.0001302401],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.8411859,0.09750375,0.01047246,0.01601201,0.0009435665,0.0001562207,0.0009639346,0.001225099,0.03153693],"genre_scores_gemma":[0.9773882,0.01166565,0.001131228,0.001698762,0.0002432495,0.00005637704,0.0003295623,0.00004561191,0.007441358],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.003035762,"threshold_uncertainty_score":0.01015562,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1710600545535365,"score_gpt":0.466605342863232,"score_spread":0.2955452883096955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}