{"id":"W2608385659","doi":"10.1146/annurev-micro-030117-020345","title":"Molecular Evolution of Antifungal Drug Resistance","year":2017,"lang":"en","type":"review","venue":"Annual Review of Microbiology","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":447,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Cryptococcus neoformans; Aspergillus fumigatus; Drug resistance; Antifungal drug; Candida albicans; Antifungal; Biology; Antifungal drugs; Drug; Microbiology; Fluconazole; Pharmacology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000622415,0.0005255916,0.001013493,0.001671335,0.0002921968,0.001519983,0.0008544518,0.001390034,0.001999082],"category_scores_gemma":[0.0008478646,0.0002670927,0.0004481598,0.00114698,0.0007049832,0.001441908,0.0007625961,0.001888088,0.001355478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001031414,"about_ca_system_score_gemma":0.00117731,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006901405,"about_ca_topic_score_gemma":0.00077838,"domain_scores_codex":[0.9996647,0.00007371092,0.00003540286,0.00006335556,0.0001199528,0.00004285135],"domain_scores_gemma":[0.9996763,0.0001175356,0.00005132233,0.0000161388,0.0001043223,0.00003436],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009567253,0.00007797327,0.0008227404,0.01098535,0.0001122754,0.0008284534,0.0002293054,0.000785082,0.01234014,0.02202238,0.0216534,0.9300472],"study_design_scores_gemma":[0.00001206739,0.00010135,0.001677809,0.002501375,0.00007677668,0.00340602,0.0001022956,0.0002103122,0.003686052,0.005461586,0.9827318,0.00003255834],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005963744,0.9959601,0.00031667,0.000719558,0.0001959336,0.000005651711,0.00002296226,0.0000118562,0.002170893],"genre_scores_gemma":[0.00454507,0.9936289,0.0003547333,0.0003838939,0.0001837587,0.000008148099,0.00004465874,0.000003184437,0.000847569],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001999082,"threshold_uncertainty_score":0.007483482,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02862641252954178,"score_gpt":0.3686939095860915,"score_spread":0.3400674970565497,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}