{"id":"W2608490856","doi":"10.1016/j.nicl.2017.04.015","title":"White matter hyperintensities are seen only in GRN mutation carriers in the GENFI cohort","year":2017,"lang":"en","type":"article","venue":"NeuroImage Clinical","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Université Laval; Occupational Cancer Research Centre; Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"Fonds de Recherche du Québec - Santé; UCLH Biomedical Research Centre; Engineering and Physical Sciences Research Council; Medical Research Council; Manchester Biomedical Research Centre; Alzheimer Nederland; NIHR Cambridge Biomedical Research Centre; University College London Hospitals NHS Foundation Trust; Alzheimer's Society; Ministero della Salute; Ente Cassa di Risparmio di Firenze; Alzheimer’s Research UK; Brain Research Trust; FP7 Information and Communication Technologies; Wolfson Foundation; National Institute for Health and Care Research; Ministry of Health; ZonMw; University College London; Wellcome Trust; Ontario Research Foundation; Seventh Framework Programme; Canadian Institutes of Health Research; Wellcome","keywords":"C9orf72; Frontotemporal dementia; Hyperintensity; Cohort; White matter; Magnetic resonance imaging; Internal medicine; Mutation; Cardiology; Dementia; Pathology; Psychology; Medicine; Oncology; Genetics; Biology; Disease; Radiology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003565095,0.0004781628,0.0005853461,0.0008050803,0.0005877346,0.0005030382,0.0003658518,0.0004553606,0.002093042],"category_scores_gemma":[0.001372795,0.0002548356,0.0003425042,0.0004217873,0.0004481874,0.0003436125,0.0004650909,0.0003877065,0.0003986828],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002733818,"about_ca_system_score_gemma":0.0002643651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006250126,"about_ca_topic_score_gemma":0.01064266,"domain_scores_codex":[0.9997501,0.00002314153,0.0000175314,0.0001176002,0.00005098962,0.00004061388],"domain_scores_gemma":[0.9996029,0.00006284617,0.0001530499,0.00005050535,0.00003113242,0.00009970092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004775687,0.00004299709,0.9906234,0.00001462181,0.00006615337,0.002067544,0.0004596754,0.00003672391,0.002769601,0.00003679876,0.0002358248,0.003169056],"study_design_scores_gemma":[0.000009510877,0.0001077285,0.9970534,0.000005915731,0.00004443751,0.002142831,0.0002098466,0.00005065311,0.0001230152,0.00003675283,0.000210008,0.000005837817],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995034,0.00007880989,0.00002157639,0.00001664022,0.000003694836,0.000003409651,0.0001231737,0.000003298601,0.0002460961],"genre_scores_gemma":[0.9994755,0.00005810251,0.00004304917,0.00001846176,0.000006840512,0.000005326985,0.000229486,0.000003318061,0.0001600467],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006250126,"threshold_uncertainty_score":0.01242745,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09794164507195438,"score_gpt":0.4078128054096284,"score_spread":0.309871160337674,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}