{"id":"W2608656888","doi":"10.1016/j.jbiotec.2017.04.028","title":"Therapeutic glycoprotein production in mammalian cells","year":2017,"lang":"en","type":"review","venue":"Journal of Biotechnology","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":291,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Chinese hamster ovary cell; Biopharmaceutical; Monoclonal antibody; Glycoprotein; Glycosylation; Glycan; Recombinant DNA; Computational biology; Cell biology; Biology; Antibody; Cell culture; Biotechnology; Immunology; Biochemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003129015,0.0002838965,0.000890942,0.000393782,0.00007691311,0.00003162996,0.0006270733,0.001187239,0.00001908192],"category_scores_gemma":[0.0001348287,0.0002157662,0.0004934311,0.000120473,0.0001502972,0.000006056699,0.0001470631,0.0006097055,0.0000150133],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005103968,"about_ca_system_score_gemma":0.0002961895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001078063,"about_ca_topic_score_gemma":0.00002429623,"domain_scores_codex":[0.9984773,0.0001324078,0.0006960238,0.0003235371,0.0001225582,0.0002481785],"domain_scores_gemma":[0.9978691,0.00000634277,0.001325488,0.0006776594,0.00006193506,0.00005942914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004121481,0.00011263,0.000005038036,0.001067178,0.000125158,0.00005324163,0.000003631821,0.000003087291,0.02518152,0.00001374229,0.002297542,0.971096],"study_design_scores_gemma":[0.0002050323,0.0005747264,0.000004155617,0.00186051,0.0001255837,0.0004970412,0.000006972159,1.156619e-7,0.03982714,0.0001352162,0.9565532,0.0002103],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001149242,0.9968587,0.00003625469,0.0001527616,0.001393526,0.0003294326,0.000008951497,0.000007802339,0.00006340167],"genre_scores_gemma":[0.002916931,0.9957405,0.0001133189,0.00002711512,0.0006780715,0.0000213613,0.00001002948,0.00003866186,0.0004539634],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9708857,"threshold_uncertainty_score":0.9157072,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04222455645348064,"score_gpt":0.3456617409848686,"score_spread":0.3034371845313879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}