{"id":"W2608722406","doi":"10.1038/ncomms15059","title":"LPP is a Src substrate required for invadopodia formation and efficient breast cancer lung metastasis","year":2017,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of Alberta; McGill University Health Centre","funders":"McGill University Health Centre; Canadian Cancer Society Research Institute; Deutsches Krebsforschungszentrum; McGill University; U.S. Department of Defense","keywords":"Invadopodia; Metastasis; Breast cancer; Proto-oncogene tyrosine-protein kinase Src; Cancer research; Lung cancer; Breast cancer metastasis; Substrate (aquarium); Biology; Medicine; Cancer; Cell biology; Cancer metastasis; Internal medicine; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008796196,0.0002125186,0.0001699272,0.0001341286,0.0002427922,0.000282316,0.0001694331,0.0001872623,0.001562888],"category_scores_gemma":[0.0001780649,0.000161864,0.0001632765,0.0001010144,0.0001870766,0.0001777399,0.0002927788,0.0003246094,0.0007882524],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000335976,"about_ca_system_score_gemma":0.0002367946,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004975382,"about_ca_topic_score_gemma":0.0006130385,"domain_scores_codex":[0.9999086,0.00001464405,0.000008408466,0.00001694677,0.00002886216,0.00002248874],"domain_scores_gemma":[0.9998559,0.00001825588,0.0000458814,0.00001503875,0.00001221457,0.00005275843],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000682923,0.00001016951,0.0002626066,0.00001422364,0.000001615763,0.0001342589,0.000006151937,0.00004700187,0.9988176,0.0001003656,0.00002974271,0.0005078447],"study_design_scores_gemma":[0.00002434769,0.0001060667,0.01858591,0.000004888157,0.000007025253,0.001465409,0.00004746455,0.002234518,0.9749141,0.0001055353,0.002499028,0.000005849154],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962599,0.0004105768,0.002175241,0.00005947231,0.000006711904,0.000009791351,0.0002580424,0.00005701588,0.0007633462],"genre_scores_gemma":[0.9970633,0.0001984391,0.001066839,0.00001237482,0.000004080184,0.00001590854,0.0006139738,0.00002034209,0.001004701],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001562888,"threshold_uncertainty_score":0.0052284,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02619496905652125,"score_gpt":0.3314998138251432,"score_spread":0.3053048447686219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}