{"id":"W2608736608","doi":"10.1093/nar/gkx320","title":"PRISM 3: expanded prediction of natural product chemical structures from microbial genomes","year":2017,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":351,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Prism; Natural product; Computational biology; Biology; Genome; Gene; Genetics; Biochemistry; Optics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001255902,0.001648799,0.0009000353,0.001382581,0.0004880239,0.001294582,0.001507324,0.0008468844,0.005402727],"category_scores_gemma":[0.003378651,0.0008786793,0.002714566,0.001654561,0.0003923399,0.001339805,0.001752619,0.001602606,0.002242084],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008565501,"about_ca_system_score_gemma":0.00253795,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004784609,"about_ca_topic_score_gemma":0.008923837,"domain_scores_codex":[0.999361,0.0001291166,0.00004549492,0.0002308971,0.0001808765,0.0000526817],"domain_scores_gemma":[0.9991026,0.0004087714,0.00009637621,0.0001748658,0.0001411536,0.00007634785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.004696478,0.0006984923,0.03410247,0.003861343,0.001139541,0.001463806,0.0004693482,0.4465115,0.1433591,0.01520524,0.09845709,0.2500356],"study_design_scores_gemma":[0.0003280808,0.0003192521,0.005963489,0.00007203576,0.0001732674,0.0003328407,0.0000696591,0.9204786,0.03289488,0.01011745,0.0291642,0.00008621289],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.1884926,0.001267454,0.5801388,0.0008538729,0.0001908314,0.0003554698,0.09317916,0.1272155,0.008306237],"genre_scores_gemma":[0.2628762,0.0008857336,0.5917979,0.000287405,0.00005673186,0.0003063891,0.1389143,0.002948932,0.001926491],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.005402727,"threshold_uncertainty_score":0.01807386,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04620075524575611,"score_gpt":0.3299303622149252,"score_spread":0.283729606969169,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}