{"id":"W2608737901","doi":"10.1038/mp.2017.86","title":"MeCP2-regulated miRNAs control early human neurogenesis through differential effects on ERK and AKT signaling","year":2017,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":311,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Institute of Mental Health","keywords":"MECP2; Neurogenesis; Rett syndrome; Biology; Protein kinase B; microRNA; Gene knockdown; MAPK/ERK pathway; Neural stem cell; Induced pluripotent stem cell; Neuroscience; Corticogenesis; Epigenetics; Cell biology; Signal transduction; Progenitor cell; Stem cell; Embryonic stem cell; Genetics; Cell culture","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001534756,0.0003088747,0.000210626,0.0002314612,0.0002210888,0.0005462944,0.0001974385,0.0002043716,0.00143148],"category_scores_gemma":[0.0002645328,0.0002167465,0.0002564119,0.0001036124,0.000226183,0.0003408174,0.0004477386,0.0005175743,0.0003779736],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004007428,"about_ca_system_score_gemma":0.0003436587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001049604,"about_ca_topic_score_gemma":0.002105126,"domain_scores_codex":[0.9997817,0.00002098268,0.00001312111,0.00006072036,0.00004514549,0.000078381],"domain_scores_gemma":[0.9999228,0.00001013973,0.00002347184,0.000008848129,0.0000153805,0.00001944344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006516511,0.00002637147,0.002314575,0.00005228422,0.00002311525,0.0001766376,0.00004875917,0.0001686338,0.9889411,0.0009224825,0.0001840591,0.006490323],"study_design_scores_gemma":[0.00007689762,0.0001542138,0.0593508,0.00002034891,0.00006613361,0.0006787308,0.0001541595,0.001970943,0.9296464,0.0006152464,0.00724737,0.000018766],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860525,0.004908611,0.003111711,0.0002289385,0.00009453336,0.00002073424,0.0006358499,0.0001109131,0.004836375],"genre_scores_gemma":[0.9943823,0.0008078331,0.001149343,0.00007198586,0.00001307917,0.00001778848,0.000279506,0.00003190992,0.003246304],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00143148,"threshold_uncertainty_score":0.004788756,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005482012824258296,"score_gpt":0.2347386831047348,"score_spread":0.2292566702804765,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}