{"id":"W2608751136","doi":"10.1016/j.bpj.2017.03.014","title":"Mapping Ryanodine Binding Sites in the Pore Cavity of Ryanodine Receptors","year":2017,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Innovates - Health Solutions","keywords":"Ryanodine receptor; RYR1; Ryanodine receptor 2; Biology; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000293233,0.0001980327,0.0004361485,0.0002796044,0.000601542,0.0006543289,0.00085136,0.0007338155,0.001689083],"category_scores_gemma":[0.0006586318,0.0003676878,0.0003336978,0.0002496823,0.0006107553,0.0005583455,0.0004147994,0.0008028012,0.0005835156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005316085,"about_ca_system_score_gemma":0.0004663015,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001303257,"about_ca_topic_score_gemma":0.001948939,"domain_scores_codex":[0.9998053,0.00003489435,0.00001129936,0.00005140433,0.00006120108,0.00003599638],"domain_scores_gemma":[0.999522,0.0002066634,0.00009388599,0.00005223051,0.00005437203,0.00007086569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0002806867,0.00002737755,0.0001804664,0.00002967328,0.000003613304,0.0000665304,0.00004284814,0.0002722328,0.9974092,0.0004430205,0.00003252914,0.001211888],"study_design_scores_gemma":[0.00009556693,0.0001959583,0.009572115,0.00001838492,0.00002484793,0.0007659689,0.0001622828,0.005819845,0.980408,0.001072744,0.001823917,0.00004021273],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901825,0.0005452824,0.007957841,0.0001260476,0.00001244933,0.0000211706,0.00009782488,0.00003438292,0.00102262],"genre_scores_gemma":[0.9909841,0.0002803585,0.007366088,0.00005567665,0.000007274922,0.00002044555,0.0001254722,0.00002709881,0.001133341],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001689083,"threshold_uncertainty_score":0.00565052,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02819400686422866,"score_gpt":0.2758513606473497,"score_spread":0.2476573537831211,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}