{"id":"W2608771854","doi":"10.1038/labinvest.2017.33","title":"Disruption of direct 3D telomere–TRF2 interaction through two molecularly disparate mechanisms is a hallmark of primary Hodgkin and Reed–Sternberg cells","year":2017,"lang":"en","type":"article","venue":"Laboratory Investigation","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Research Manitoba; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Telomere; Biology; Reed–Sternberg cell; Genetics; DNA; Immunology; Lymphoma; Hodgkin lymphoma","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003402903,0.000246005,0.0005141389,0.0001336807,0.0001681164,0.00006110235,0.0001582117,0.0001461621,0.00003083114],"category_scores_gemma":[0.000180822,0.0002343562,0.0000661848,0.0002263514,0.0003942458,0.000872748,0.00007456529,0.0001974915,0.000008728553],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008236232,"about_ca_system_score_gemma":0.0001752027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005357016,"about_ca_topic_score_gemma":0.00007051909,"domain_scores_codex":[0.9982702,0.0001483466,0.0005398772,0.00041728,0.0004162683,0.000208091],"domain_scores_gemma":[0.9978395,0.00006087185,0.0008216114,0.0007355909,0.0003913339,0.000151094],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002119814,0.00008899502,0.0207363,0.0004795588,0.0000774298,0.00001444087,0.001809275,0.000007378222,0.9730845,0.0009565109,0.0001642254,0.002369414],"study_design_scores_gemma":[0.001322032,0.000316563,0.1033166,0.000674247,0.000181952,0.000008743473,0.0001987567,0.0006173076,0.891546,0.001142803,0.0004347194,0.0002402998],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953518,0.0003071147,0.001691741,0.0003873086,0.0003595973,0.0004373702,0.00009656198,0.00004689512,0.001321602],"genre_scores_gemma":[0.9897949,0.0002809101,0.008923859,0.0006399211,0.00007852024,0.00002182072,0.00006290262,0.00003569578,0.000161547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08258027,"threshold_uncertainty_score":0.9556768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02708114087870843,"score_gpt":0.2892938646974398,"score_spread":0.2622127238187313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}