{"id":"W2608835133","doi":"10.1038/ng.3849","title":"Genomic consequences of aberrant DNA repair mechanisms stratify ovarian cancer histotypes","year":2017,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":290,"is_retracted":false,"has_abstract":false,"ca_institutions":"Vancouver General Hospital; Canada's Michael Smith Genome Sciences Centre; Université de Montréal; Child and Family Research Institute; Centre Hospitalier de l’Université de Montréal; University of British Columbia; BC Cancer Agency","funders":"BC Cancer Agency; Jikei University School of Medicine; University of British Columbia","keywords":"Biology; Microsatellite instability; Ovarian cancer; Cell of origin; Point mutation; DNA mismatch repair; Genome instability; Serous fluid; Genetics; Cancer research; Mutation; Cancer; Germline mutation; DNA repair; DNA damage; Microsatellite; Gene; DNA; Allele","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003244312,0.000211593,0.0003138342,0.00121632,0.000216933,0.0006487311,0.0002572359,0.0004759339,0.00306877],"category_scores_gemma":[0.001210072,0.0001880158,0.0003013949,0.000516958,0.0003038563,0.0002827313,0.0004835365,0.000419364,0.00039105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002256933,"about_ca_system_score_gemma":0.0001384716,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005815887,"about_ca_topic_score_gemma":0.00107545,"domain_scores_codex":[0.999733,0.00005615089,0.00001863614,0.0000606961,0.00005644328,0.00007498193],"domain_scores_gemma":[0.9993134,0.0002038739,0.0002652502,0.00009515818,0.00004306412,0.00007932828],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001196983,0.00004668869,0.8973728,0.00003975692,0.0002639246,0.0007504715,0.0001608334,0.0007383787,0.07458368,0.001094004,0.0005580307,0.02319452],"study_design_scores_gemma":[0.00002400322,0.0001294725,0.9858286,0.00001587489,0.000169811,0.002131049,0.0001974736,0.000772681,0.006828123,0.00210037,0.001789159,0.00001347621],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960828,0.001007904,0.0006446695,0.0002299659,0.00001757129,0.00001099959,0.0004085132,0.00002532721,0.001572264],"genre_scores_gemma":[0.9988663,0.0002626945,0.0002086122,0.00006284061,0.00001471387,0.000003557648,0.0002475818,0.00001420181,0.0003195226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00306877,"threshold_uncertainty_score":0.01026607,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02205165281441145,"score_gpt":0.3069829118030615,"score_spread":0.28493125898865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}