{"id":"W2608835133","doi":"10.1038/ng.3849","title":"Genomic consequences of aberrant DNA repair mechanisms stratify ovarian cancer histotypes","year":2017,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":290,"is_retracted":false,"has_abstract":false,"ca_institutions":"Vancouver General Hospital; Canada's Michael Smith Genome Sciences Centre; Université de Montréal; Child and Family Research Institute; Centre Hospitalier de l’Université de Montréal; University of British Columbia; BC Cancer Agency","funders":"BC Cancer Agency; Jikei University School of Medicine; University of British Columbia","keywords":"Biology; Microsatellite instability; Ovarian cancer; Cell of origin; Point mutation; DNA mismatch repair; Genome instability; Serous fluid; Genetics; Cancer research; Mutation; Cancer; Germline mutation; DNA repair; DNA damage; Microsatellite; Gene; DNA; Allele","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001061594,0.0001684246,0.0003365925,0.00004681733,0.0001561435,0.00002549639,0.0001844026,0.0002966681,0.0002865788],"category_scores_gemma":[0.00003562915,0.0001343646,0.0001424033,0.00003594882,0.0001826864,0.00002648811,0.00004041802,0.0002581147,0.000007612821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001420519,"about_ca_system_score_gemma":0.0004358694,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003248138,"about_ca_topic_score_gemma":0.0003865683,"domain_scores_codex":[0.9989786,0.00001745885,0.000242074,0.0003119071,0.0002512123,0.0001987541],"domain_scores_gemma":[0.9987292,0.00002106707,0.000239671,0.0007592109,0.0001411199,0.0001096942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009917009,0.001412358,0.4686339,0.001043494,0.003830065,0.0008663857,0.001525185,0.0001140131,0.3776813,0.0441315,0.02285357,0.07691649],"study_design_scores_gemma":[0.002092131,0.000530674,0.7205062,0.0002311143,0.0007029039,0.00003720292,0.00004303523,0.00008430585,0.2562702,0.002860102,0.01641727,0.0002248786],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9561377,0.02648769,0.00007208213,0.006922376,0.00160973,0.0007110758,0.0001877137,0.00006923272,0.007802462],"genre_scores_gemma":[0.9857689,0.002265245,0.01068959,0.0004563723,0.0002301845,0.00003435666,0.00001168687,0.00002233309,0.0005213356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2518722,"threshold_uncertainty_score":0.5479228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02205165281441145,"score_gpt":0.3069829118030615,"score_spread":0.28493125898865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}