{"id":"W2608835695","doi":"10.1016/j.bbamem.2017.04.018","title":"Arginine-lysine positional swap of the LL-37 peptides reveals evolutional advantages of the native sequence and leads to bacterial probes","year":2017,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Biomembranes","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; Health Sciences Centre","funders":"National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; China Scholarship Council; Ciência sem Fronteiras; Conselho Nacional de Desenvolvimento Científico e Tecnológico","keywords":"Phosphatidylglycerol; Biochemistry; Peptide; Cardiolipin; Antimicrobial peptides; Cathelicidin; Biology; Escherichia coli; Bacteria; Peptide sequence; Chemistry; Membrane; Phospholipid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002206084,0.0002363561,0.0002243456,0.0001129008,0.0001285957,0.0003179138,0.0002596786,0.0002391739,0.0009155265],"category_scores_gemma":[0.0002344019,0.0001560669,0.0001618912,0.0001178542,0.0003858307,0.0002278888,0.0002586406,0.0005537762,0.0003671882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004467276,"about_ca_system_score_gemma":0.0002163761,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005030099,"about_ca_topic_score_gemma":0.000899144,"domain_scores_codex":[0.9998634,0.00002781632,0.00001111164,0.00002645125,0.00003086162,0.00004036427],"domain_scores_gemma":[0.9998469,0.00003840146,0.00003681213,0.00002923867,0.00001009254,0.00003841809],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008816012,0.000008927162,0.00008958338,0.000008851272,0.000002015345,0.00006196904,0.00001498884,0.0001417163,0.9983796,0.0002823035,0.00001525084,0.0009065691],"study_design_scores_gemma":[0.000006172923,0.00005259379,0.0003696557,0.000001737852,0.000005381409,0.0001248077,0.00001353935,0.0005081317,0.9979768,0.00006004841,0.0008773145,0.000003837771],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955366,0.0003660209,0.002922975,0.00007407009,0.00001991453,0.000008330159,0.00007610596,0.00006087496,0.0009351592],"genre_scores_gemma":[0.9954105,0.0002215868,0.003087339,0.00004323616,0.000004237808,0.000005301798,0.0001000588,0.00003948029,0.001088232],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009155265,"threshold_uncertainty_score":0.003241181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0161194242902604,"score_gpt":0.2656645012387026,"score_spread":0.2495450769484422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}