{"id":"W2608944992","doi":"10.1016/j.biopsych.2017.02.772","title":"705. Using iPS Derived Neurons and GWAS Together to Identify Genes for Lithium Response","year":2017,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"","keywords":"Genome-wide association study; Pharmacogenomics; Lithium (medication); Gene; Computational biology; Biology; Neuroscience; Genetics; Single-nucleotide polymorphism; Endocrinology; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006377557,0.0004639354,0.0003571552,0.0007842881,0.0003771828,0.0009453483,0.0003570949,0.0007466218,0.007770611],"category_scores_gemma":[0.0009588813,0.0002227952,0.000969885,0.0006581788,0.0002435471,0.0002861226,0.0004614974,0.0007980703,0.001391473],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002838419,"about_ca_system_score_gemma":0.0004698291,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00244615,"about_ca_topic_score_gemma":0.007155962,"domain_scores_codex":[0.9997019,0.00006053051,0.00002621007,0.00008723995,0.00008792971,0.00003616131],"domain_scores_gemma":[0.9996277,0.0001569702,0.00006898703,0.00004794747,0.0000553432,0.0000430462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002176077,0.0003695863,0.1735094,0.0007363832,0.00230093,0.003128947,0.0004466395,0.002373916,0.6096184,0.004902978,0.01646023,0.1839765],"study_design_scores_gemma":[0.0008049221,0.001342796,0.6103874,0.0005735149,0.005283359,0.008296376,0.000861324,0.01668466,0.2560307,0.01349594,0.08606354,0.0001753599],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8752847,0.003103883,0.04955449,0.003152696,0.0008375078,0.000263825,0.03197232,0.001590146,0.03424033],"genre_scores_gemma":[0.9301144,0.001986356,0.02848143,0.003681686,0.0001678114,0.0003304856,0.01597822,0.0004966957,0.01876296],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007770611,"threshold_uncertainty_score":0.02599525,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1006480442117161,"score_gpt":0.3917020663800926,"score_spread":0.2910540221683764,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}