{"id":"W2608961468","doi":"10.1021/acschembio.7b00041","title":"Discovery and Characterization of a Eukaryotic Initiation Factor 4A-3-Selective Inhibitor That Suppresses Nonsense-Mediated mRNA Decay","year":2017,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"","keywords":"Helicase; Biology; Eukaryotic initiation factor; Allosteric regulation; RNA Helicase A; Biochemistry; Eukaryotic translation; RNA; Initiation factor; Cell biology; Ribosome; Biophysics; Messenger RNA; Translation (biology); Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007571121,0.000151547,0.000215797,0.00003085707,0.00008701993,0.00003555234,0.00017918,0.0003210589,0.00000848048],"category_scores_gemma":[0.000411021,0.0001299947,0.00004709033,0.00002360241,0.0002072587,0.0000214257,0.0001531029,0.00006974199,0.000003135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007884193,"about_ca_system_score_gemma":0.00004275134,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000121431,"about_ca_topic_score_gemma":0.000003605279,"domain_scores_codex":[0.9991741,0.00007188729,0.0001860557,0.0003222112,0.00005901053,0.0001867875],"domain_scores_gemma":[0.9992443,0.00006957468,0.0002588542,0.0003047274,0.00007178875,0.00005072459],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001777085,0.00003499203,0.01335128,0.00001918658,0.00004036535,8.938504e-7,0.00003796618,1.695705e-8,0.984955,0.00006271927,0.00001296969,0.00130697],"study_design_scores_gemma":[0.0003837634,0.0001623412,0.02033818,0.00001877873,0.00001587509,0.000007348382,0.000009104529,0.000002613505,0.9785629,0.0001837852,0.0001675936,0.0001476981],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986407,0.0001067138,0.0004676351,0.0001658424,0.0001329357,0.0001867195,0.0001765605,0.000008879704,0.0001140613],"genre_scores_gemma":[0.9986885,0.0003240402,0.0001096911,0.00008728364,0.0001617503,0.00002425527,0.0005578808,0.00001545315,0.00003118023],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006986898,"threshold_uncertainty_score":0.530103,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01624813642081372,"score_gpt":0.2493223191311459,"score_spread":0.2330741827103321,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}