{"id":"W2609007084","doi":"10.1038/s41598-017-01554-1","title":"Construction of a highly efficient CRISPR/Cas9-mediated duck enteritis virus-based vaccine against H5N1 avian influenza virus and duck Tembusu virus infection","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Agriculture","funders":"National Key Research and Development Program of China; Huazhong Agricultural University","keywords":"Virology; Influenza A virus subtype H5N1; CRISPR; Biology; Hemagglutinin (influenza); Virus; Cas9; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005852333,0.0002396613,0.0002651856,0.0001811316,0.0004519555,0.0002337918,0.0001399624,0.000175221,0.00002193998],"category_scores_gemma":[0.0003550886,0.0002439404,0.0001181125,0.0001380905,0.0003041583,0.00001582691,0.0001497498,0.0001110489,0.000005446968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002724665,"about_ca_system_score_gemma":0.0001089067,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004612449,"about_ca_topic_score_gemma":0.0006369227,"domain_scores_codex":[0.9979846,0.00003854464,0.0005929541,0.0007762203,0.0002902962,0.0003173947],"domain_scores_gemma":[0.9979487,0.00001017189,0.0005053874,0.001127783,0.0002419324,0.0001660425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006110039,0.00008882832,0.01833392,0.00006777498,0.00003413757,0.00004771698,0.00006659264,0.001555119,0.9768171,0.000002337736,0.0005399661,0.002385398],"study_design_scores_gemma":[0.0006004662,0.0001240654,0.03904264,0.00007194127,0.0000362631,0.0001337859,0.00002520441,0.0007850209,0.9419212,0.0000247817,0.01697028,0.0002643941],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935433,0.0005136031,0.001827385,0.00003705036,0.003479371,0.0003289672,0.00003867322,0.00003528929,0.0001963153],"genre_scores_gemma":[0.9989647,0.0001181787,0.0004131373,0.00004558092,0.000127998,0.0000214733,0.0001565683,0.00002685697,0.0001255009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03489596,"threshold_uncertainty_score":0.9947601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00795419727517677,"score_gpt":0.2813826734864938,"score_spread":0.273428476211317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}