{"id":"W2609007084","doi":"10.1038/s41598-017-01554-1","title":"Construction of a highly efficient CRISPR/Cas9-mediated duck enteritis virus-based vaccine against H5N1 avian influenza virus and duck Tembusu virus infection","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Agriculture","funders":"National Key Research and Development Program of China; Huazhong Agricultural University","keywords":"Virology; Influenza A virus subtype H5N1; CRISPR; Biology; Hemagglutinin (influenza); Virus; Cas9; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001938112,0.0003934919,0.0004253133,0.0001784405,0.0001733265,0.0002900295,0.0003663255,0.0003826882,0.000740046],"category_scores_gemma":[0.0001460236,0.0002019027,0.0003378617,0.0001119787,0.0002006038,0.0001840395,0.0003060504,0.000519868,0.0002602318],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003283356,"about_ca_system_score_gemma":0.0002416179,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001010328,"about_ca_topic_score_gemma":0.001482906,"domain_scores_codex":[0.9998062,0.00002116225,0.00003299394,0.00005434628,0.00005234486,0.00003292348],"domain_scores_gemma":[0.9999235,0.00001026517,0.0000271236,0.000009196394,0.000009452212,0.00002042223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004815721,0.00002449924,0.000172344,0.00007592966,0.00001154652,0.0000890094,0.00002630802,0.0002754761,0.9966111,0.0002044721,0.0000759916,0.002385221],"study_design_scores_gemma":[0.00002506632,0.0003205938,0.002153031,0.00001244909,0.00003983502,0.0004512966,0.0000418111,0.006431936,0.9823892,0.0000621797,0.008054153,0.00001849826],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9535106,0.001039936,0.04080966,0.0001285483,0.0001205055,0.0002436558,0.0008717317,0.0003223442,0.002953028],"genre_scores_gemma":[0.9576994,0.0006843758,0.03403905,0.00007577917,0.00001015653,0.0001205114,0.001322617,0.00005786833,0.005990197],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001010328,"threshold_uncertainty_score":0.002475739,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00795419727517677,"score_gpt":0.2813826734864938,"score_spread":0.273428476211317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}