{"id":"W2609189265","doi":"10.1101/129536","title":"A human huntingtin SNP alters post-translational modification and pathogenic proteolysis of the protein causing Huntington disease","year":2017,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC; CHDI Foundation","keywords":"Huntingtin; Myristoylation; Proteolysis; Biology; Huntington's disease; Genetics; Neurodegeneration; SNP; Gene; Cell biology; Phosphorylation; Single-nucleotide polymorphism; Disease; Mutant; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002068626,0.0003175624,0.0002761021,0.0002182862,0.0002322099,0.0002016874,0.0001176884,0.0005595242,0.00156241],"category_scores_gemma":[0.0002392989,0.0000953288,0.0002870073,0.0001694497,0.0002799472,0.00008259185,0.0002372427,0.000328876,0.0002744798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001403513,"about_ca_system_score_gemma":0.0001206313,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007754276,"about_ca_topic_score_gemma":0.001093214,"domain_scores_codex":[0.9998475,0.0000343005,0.00002175838,0.00004786106,0.00003180417,0.0000166463],"domain_scores_gemma":[0.9998389,0.0000635863,0.00004114666,0.00001871306,0.0000131649,0.00002448272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006028535,0.00009113604,0.01559098,0.00005054945,0.000107807,0.006539728,0.0001264663,0.0002807314,0.9717218,0.0003573314,0.0003620928,0.004168551],"study_design_scores_gemma":[0.0001212376,0.001088059,0.298187,0.00004514886,0.0003100484,0.03034351,0.0001977769,0.003984376,0.6597889,0.0009659964,0.004923254,0.00004487592],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972222,0.0002470006,0.001144335,0.00009518681,0.00003738627,0.00001330589,0.0004600625,0.00003041454,0.00075021],"genre_scores_gemma":[0.9983736,0.00009600329,0.000618453,0.0001011314,0.00001295812,0.000006021381,0.0002416945,0.00001231959,0.0005378673],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00156241,"threshold_uncertainty_score":0.005226791,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0320498858641544,"score_gpt":0.2590886803394222,"score_spread":0.2270387944752678,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}