{"id":"W2609313774","doi":"10.3892/ijo.2017.3975","title":"Gene silencing of indoleamine 2,3-dioxygenase hinders tumor growth through angiogenesis inhibition","year":2017,"lang":"en","type":"article","venue":"International Journal of Oncology","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Natural Science Foundation of China","keywords":"Gene silencing; Angiogenesis; Gene knockdown; Cancer research; Biology; Small hairpin RNA; Small interfering RNA; Oncogene; Indoleamine 2,3-dioxygenase; RNA interference; Neovascularization; Cancer; Cell cycle; Transfection; Apoptosis; RNA; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000100583,0.0002336697,0.0002695161,0.0001743705,0.00009501378,0.0002096339,0.0001719738,0.0002067098,0.0005941398],"category_scores_gemma":[0.00006474626,0.00008067454,0.000208359,0.0001023662,0.0001887551,0.0001520433,0.0001026172,0.0003880134,0.0001242928],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002521322,"about_ca_system_score_gemma":0.0002593379,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006994231,"about_ca_topic_score_gemma":0.001230461,"domain_scores_codex":[0.9999349,0.000008041197,0.000006031028,0.00001433317,0.00001514197,0.00002145031],"domain_scores_gemma":[0.9999565,0.00001036906,0.00001327427,0.00000407335,0.000005102873,0.00001066718],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005046841,0.0000292339,0.00007532661,0.00002544542,0.000003285011,0.00002587627,0.000009581829,0.00006640244,0.9982888,0.0001258111,0.00004091802,0.001258814],"study_design_scores_gemma":[0.00001419942,0.000238252,0.001258815,0.000003325729,0.00001667812,0.0000690356,0.00001381489,0.001831706,0.9948999,0.00004729874,0.001604549,0.000002338513],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912525,0.001839329,0.004957895,0.0001475216,0.00004179189,0.00002975728,0.0001855205,0.0001195423,0.001426115],"genre_scores_gemma":[0.9945451,0.001148292,0.002106671,0.00003683117,0.000007188893,0.00004068965,0.0001766118,0.00001286436,0.001925622],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006994231,"threshold_uncertainty_score":0.001987576,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04630004268842516,"score_gpt":0.3319601476051523,"score_spread":0.2856601049167271,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}