{"id":"W2609378053","doi":"10.1016/j.pnpbp.2017.04.030","title":"Rat brain CYP2D enzymatic metabolism alters acute and chronic haloperidol side-effects by different mechanisms","year":2017,"lang":"en","type":"article","venue":"Progress in Neuro-Psychopharmacology and Biological Psychiatry","topic":"Diet and metabolism studies","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre for Addiction and Mental Health; University of Toronto","funders":"Canadian Institutes of Health Research; European College of Neuropsychopharmacology","keywords":"Haloperidol; Catalepsy; Pharmacology; Tardive dyskinesia; Antipsychotic; Metabolite; Chemistry; Medicine; Internal medicine; Dopamine; Schizophrenia (object-oriented programming); Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001121454,0.0004650628,0.0004315531,0.0005494986,0.000220497,0.0002791266,0.0001616956,0.0002867529,0.002756286],"category_scores_gemma":[0.0001705126,0.0003249621,0.0004251739,0.0002768951,0.0004804861,0.0003348658,0.0001710997,0.0006674945,0.0003991026],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004327362,"about_ca_system_score_gemma":0.0002940656,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001640677,"about_ca_topic_score_gemma":0.003731072,"domain_scores_codex":[0.9998854,0.00002432179,0.000006916033,0.0000272718,0.00001925965,0.0000367612],"domain_scores_gemma":[0.9998651,0.00001638285,0.00004022005,0.00002661021,0.00001587472,0.00003595119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01205972,0.0004074945,0.004356343,0.00007639884,0.0001085812,0.0001791934,0.00005967825,0.0001110304,0.9728038,0.0001288664,0.0001710032,0.009537996],"study_design_scores_gemma":[0.0002622463,0.004236595,0.06266133,0.00001053824,0.0002448467,0.0004956108,0.0001305633,0.0005391286,0.929859,0.0001999726,0.001336862,0.00002322256],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973379,0.0009629311,0.0006784209,0.0000794445,0.00002348921,0.00001191654,0.0003418626,0.00005526875,0.0005086706],"genre_scores_gemma":[0.9949117,0.00117889,0.0007763745,0.00007365166,0.00001686603,0.00003307141,0.0006295793,0.00003321634,0.002346639],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002756286,"threshold_uncertainty_score":0.009220719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01564529189261275,"score_gpt":0.3275574128167959,"score_spread":0.3119121209241831,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}