{"id":"W2609394914","doi":"10.1177/1352458517703799","title":"Treatment response to dimethyl fumarate is characterized by disproportionate CD8+ T cell reduction in MS","year":2017,"lang":"en","type":"article","venue":"Multiple Sclerosis Journal","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Deutsche Forschungsgemeinschaft; Teva Pharmaceutical Industries; CSL Behring; Bayer","keywords":"Dimethyl fumarate; CD8; Multiple sclerosis; CD19; Lymphocyte; Flow cytometry; Immune system; Immunology; Medicine; Internal medicine; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004786736,0.0001359942,0.000272166,0.0005385798,0.0001923072,0.0002575716,0.0001474538,0.0002867209,0.001475563],"category_scores_gemma":[0.001204759,0.00008689781,0.0002168651,0.0003390323,0.0001663821,0.0001789329,0.0001150802,0.0002113728,0.0002512198],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001472045,"about_ca_system_score_gemma":0.00007796131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003213244,"about_ca_topic_score_gemma":0.0002969942,"domain_scores_codex":[0.9997483,0.00007486703,0.00003815816,0.00005150794,0.0000545138,0.00003278768],"domain_scores_gemma":[0.9990807,0.0002243083,0.0005231953,0.00003903533,0.00006957525,0.00006328704],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002300638,0.00008788565,0.9645341,0.00007643172,0.00007691593,0.0004953122,0.0001469529,0.00009048221,0.01334272,0.00002904016,0.0001093263,0.01871021],"study_design_scores_gemma":[0.00001641112,0.0009606099,0.9924244,0.00001211895,0.00006443739,0.002903263,0.00008111734,0.0001089979,0.002870115,0.00004216664,0.000512643,0.000003795294],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985189,0.000946697,0.00009704278,0.00001792567,0.000002963935,0.000006459096,0.00006985365,0.000004964869,0.0003351799],"genre_scores_gemma":[0.9996464,0.0001324905,0.0000526879,0.00001057956,0.00000620661,0.000004044831,0.00006533683,0.000001225008,0.00008102031],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001475563,"threshold_uncertainty_score":0.004936278,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09730746843317647,"score_gpt":0.3382122425898248,"score_spread":0.2409047741566483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}