{"id":"W2609394914","doi":"10.1177/1352458517703799","title":"Treatment response to dimethyl fumarate is characterized by disproportionate CD8+ T cell reduction in MS","year":2017,"lang":"en","type":"article","venue":"Multiple Sclerosis Journal","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Deutsche Forschungsgemeinschaft; Teva Pharmaceutical Industries; CSL Behring; Bayer","keywords":"Dimethyl fumarate; CD8; Multiple sclerosis; CD19; Lymphocyte; Flow cytometry; Immune system; Immunology; Medicine; Internal medicine; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001401429,0.0004366351,0.0007947863,0.0004671555,0.001257466,0.0004537489,0.00039733,0.0001595284,0.0004112834],"category_scores_gemma":[0.001057875,0.0003431599,0.0003249124,0.0002163785,0.0002225883,0.0005407245,0.0002121373,0.0005899809,0.0002470806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001044722,"about_ca_system_score_gemma":0.0002021273,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004098732,"about_ca_topic_score_gemma":0.00004140969,"domain_scores_codex":[0.9964276,0.0003729055,0.0008554592,0.0006512987,0.0008065929,0.0008861524],"domain_scores_gemma":[0.9972478,0.0001647646,0.0005424846,0.0009132294,0.000367892,0.0007638516],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.008002591,0.0008016517,0.04697704,0.00002411579,0.0001193692,0.00003771656,0.0009359925,0.000006849516,0.8864715,2.033033e-7,0.003667549,0.05295541],"study_design_scores_gemma":[0.01273502,0.001084952,0.7824215,0.0002883736,0.00005499825,0.00006565598,0.0001983452,0.0003029166,0.1761514,0.000006803325,0.02635627,0.0003338633],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9812795,0.0003592089,0.000135582,0.0158354,0.0004937263,0.001442006,0.0001654453,0.00004668704,0.0002424585],"genre_scores_gemma":[0.9889394,0.004706673,0.001548161,0.0002176495,0.000503784,0.0002920447,0.00002864012,0.00006779144,0.003695843],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7354444,"threshold_uncertainty_score":0.9999021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09730746843317647,"score_gpt":0.3382122425898248,"score_spread":0.2409047741566483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}