{"id":"W2609422755","doi":"10.1007/s12672-017-0292-7","title":"Growth Hormone Receptor Knockdown Sensitizes Human Melanoma Cells to Chemotherapy by Attenuating Expression of ABC Drug Efflux Pumps","year":2017,"lang":"en","type":"article","venue":"Hormones and Cancer","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":false,"ca_institutions":"Heritage College","funders":"AMVETS","keywords":"Vemurafenib; Melanoma; Cancer research; Pharmacology; Efflux; Gene knockdown; Drug resistance; ATP-binding cassette transporter; Biology; Medicine; Cell culture; Transporter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006395093,0.0002009519,0.0002024942,0.0001657209,0.0001390484,0.0003589973,0.0001122791,0.0001701356,0.001826543],"category_scores_gemma":[0.0000735557,0.0001349937,0.000170252,0.0001360511,0.0001948282,0.0001904302,0.0001048321,0.0004531518,0.0003034811],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003078748,"about_ca_system_score_gemma":0.0002228254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002154519,"about_ca_topic_score_gemma":0.00347622,"domain_scores_codex":[0.9999294,0.000009362891,0.000006417071,0.00001431207,0.00001760179,0.00002286458],"domain_scores_gemma":[0.9999675,0.000006280027,0.000008661422,0.000005843355,0.000004544373,0.000007199427],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007340988,0.00002046445,0.0001583287,0.00002051253,0.000006560333,0.00002906674,0.00001250907,0.00004225787,0.9978034,0.0001076548,0.0001497036,0.001576194],"study_design_scores_gemma":[0.0000407401,0.0003695865,0.00666522,0.000005405126,0.00003766578,0.0001835872,0.00006202485,0.0008979489,0.9800577,0.00007053417,0.01160247,0.000007195541],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905148,0.004095999,0.001388583,0.0004664943,0.0001051712,0.00003159661,0.0004572451,0.0002147668,0.00272532],"genre_scores_gemma":[0.9932309,0.001538479,0.0006806902,0.00009460109,0.00001382271,0.00001562483,0.0003551242,0.00002526814,0.004045425],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002154519,"threshold_uncertainty_score":0.00611043,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008976481457474645,"score_gpt":0.2622209727446267,"score_spread":0.253244491287152,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}