{"id":"W2609558812","doi":"10.1182/blood.v128.22.899.899","title":"The Addition of Bortezomib to Standard Chemotherapy for Pediatric Acute Myeloid Leukemia Has Increased Toxicity without Therapeutic Benefit: A Report from the Children's Oncology Group","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"","keywords":"Medicine; Cytarabine; Internal medicine; Etoposide; Oncology; Mitoxantrone; Chemotherapy; Bortezomib; Induction chemotherapy; Gemtuzumab ozogamicin; Idarubicin; Leukemia; Minimal residual disease; Myeloid leukemia; Surgery; Multiple myeloma; Stem cell; CD33","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002658153,0.0003077061,0.0005034116,0.0002224518,0.0002222824,0.0004916375,0.000292637,0.0005432778,0.001385921],"category_scores_gemma":[0.004004694,0.0001168514,0.0006137026,0.0005983,0.0003583415,0.0002903767,0.0002203804,0.00139333,0.0001874641],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008552073,"about_ca_system_score_gemma":0.0009633299,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001184309,"about_ca_topic_score_gemma":0.00147218,"domain_scores_codex":[0.9990864,0.0003960079,0.0001332999,0.0000955953,0.000228406,0.0000602889],"domain_scores_gemma":[0.9956946,0.002697917,0.0007399094,0.0001763214,0.0004970877,0.0001941023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.01546227,0.0009970692,0.08298052,0.001748783,0.001001669,0.002482324,0.0003170649,0.0006831491,0.01857966,0.001439347,0.03093377,0.8433744],"study_design_scores_gemma":[0.01577012,0.04624879,0.3517943,0.001648305,0.00600899,0.02404192,0.0005897938,0.001849771,0.05880779,0.001718911,0.4914075,0.0001137513],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7771674,0.1836401,0.002745271,0.01382556,0.0009826513,0.0005402142,0.001116304,0.00009880831,0.01988366],"genre_scores_gemma":[0.9079871,0.07147288,0.003019653,0.0116547,0.001545698,0.0002285432,0.001148702,0.00005407967,0.002888609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002658153,"threshold_uncertainty_score":0.01405787,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01614106622181949,"score_gpt":0.2901137362243739,"score_spread":0.2739726700025544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}