{"id":"W2609900216","doi":"10.1182/blood.v128.22.2095.2095","title":"TTI-281, an Orally Bioavailable Bromodomain and Extraterminal Domain (BET) Inhibitor, Is a Promising Candidate for the Treatment of Multiple Myeloma","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Trillium Therapeutics (Canada)","funders":"","keywords":"Pharmacology; Bioavailability; In vivo; ADME; Bromodomain; Oral administration; Pharmacokinetics; IC50; Chemistry; In vitro; Biology; Biochemistry; Epigenetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001387152,0.0002927417,0.0003362957,0.0001890176,0.0001131993,0.0002086798,0.0002517478,0.0002583826,0.001824992],"category_scores_gemma":[0.00006430237,0.00009642351,0.0002345539,0.0001795942,0.0001299198,0.0001656528,0.0001296436,0.0005908607,0.0005419664],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002173533,"about_ca_system_score_gemma":0.0001801903,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003303196,"about_ca_topic_score_gemma":0.0007736304,"domain_scores_codex":[0.9999622,0.000005662836,0.00000224153,0.000007143064,0.00001291147,0.000009869797],"domain_scores_gemma":[0.9999647,0.000005177899,0.00001148269,0.000001591165,0.000005041657,0.00001211804],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007136011,0.0005027843,0.001348656,0.0005460214,0.00005455278,0.0004196449,0.00002712985,0.001255515,0.9426757,0.0005066051,0.001828311,0.05012154],"study_design_scores_gemma":[0.0009656459,0.01362861,0.0141405,0.00008853645,0.0002165835,0.003035658,0.00006905505,0.006006489,0.8765366,0.0005327074,0.08472545,0.00005418529],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8429141,0.1280022,0.01274266,0.001802903,0.0003094135,0.0002679904,0.001401141,0.0003453192,0.01221426],"genre_scores_gemma":[0.9565353,0.02816372,0.004160941,0.0005364199,0.00008747292,0.00009035846,0.001793578,0.00002239299,0.00860981],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001824992,"threshold_uncertainty_score":0.006105244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03026844614524714,"score_gpt":0.2984379529543976,"score_spread":0.2681695068091505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}